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Genomic & Epigenomic Complex Disease Epidemiology

Objective

Genetic and epigenetic epidemiology are rapidly developing aspects of population-based health research that have clear translational potential. These endeavours both benefit considerably from extensive international collaborations. Establishing robust associations between genetic variation and common complex disease phenotypes requires very large sample sizes than can only realistically be generated through collaborative work. Furthermore, exploring associations in populations with different historical origins contributes to location of functional variation. Interactions of genetic variation and environmental exposures are best studied against a background of widely different environments, something that is best leveraged between, rather than within, countries. Epigenetic patterns are clearly influenced by exposures such as 1-carbon composition of the diet that differ between countries, allowing considerably greater power for establishing associations. Triangulating environmental exposures, genetic variation and epigenetic mediation offers to provide a step-change in ability to detect causal associations, of direct relevance to therapeutic and preventive activities. GeoCoDE will assemble a group of investigators who are custodians of world-leading population resources, have access to appropriate technologies and have been involved in advancing methods of data analysis. Through exchange visits of senior and junior research staff, workshops and extensive networking we will contribute to major advance in European capacity in this field.

Call for proposal

FP7-PEOPLE-2009-IRSES
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Coordinator

UNIVERSITY OF BRISTOL
Address
Beacon House Queens Road
BS8 1QU Bristol
United Kingdom

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elodie Mahieu-Wedande (Ms.)
EU contribution
€ 365 400

Participants (7)

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 171 000
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aleona Blinova (Ms.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 45 000
Address
Highfield
SO17 1BJ Southampton

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Caroline Fall (Prof.)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 37 800
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enda Clarke (Dr.)
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
France
EU contribution
€ 54 000
Address
25 Avenue Tony Garnier
69007 Lyon 7eme

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Activity type
Research Organisations
Administrative Contact
Olaf Kelm (Dr.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 30 600
Address
Via Giuseppe Verdi 8
10124 Torino

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emanuela Ciliberto (Dr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 41 400
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Koos Lubbe (Mr.)
FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL
Spain
EU contribution
€ 27 000
Address
Calle Doctor Aiguader 88
08003 Barcelona

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Activity type
Research Organisations
Administrative Contact
Gemma Perelló (Ms.)