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EUCOMM: Tools for Functional Annotation of the Mouse Genome

EUCOMM: Tools for Functional Annotation of the Mouse Genome

Objective

The EUCOMMTOOLS Collaborative Project responds to the topic ‘HEALTH.2010.2.1.1-1: Large-scale efforts in mouse functional genomics to determine the functions of genes and their involvement in disease.’ EUCOMMTOOLS will provide, in a systematic high-throughput way, genetic tools and resources contributing to the determination of every gene’s function in any cell type of the entire organism at any given point in time.
To contribute to the IKMC goals, EUCOMMTOOLS will establish 250 BAC-CreERT2 transgenic mice allowing inducible conditional gene inactivation in most cell types of the organism at any given point in time. Furthermore, EUCOMMTOOLS will establish 3.500 additional, conditionally targeted mouse ES cells to complete the IKMC resource. In addition, various important technological developments will valorise the EUCOMMTOOLS resources: a genetic toolkit for multipurpose usage of the conditional knockout alleles, and improvements of the Cre-recombinase function. The EUCOMMTOOLS Cre transgenic resource as well as its library of conditionally mutated mouse ES cells enables the establishment of mutant mice world-wide in a standardized, cost-effective and time-saving manner, making mouse mutants more easily available to the wider biomedical research community than possible previously. All EUCOMMTOOLS vectors, mutant ES cells and mice will be displayed via the EUCOMMTOOLS web portal and will be distributed by EuMMCR and EMMA to the scientific community.
In general, EUCOMMTOOLS fosters existing European consortia which address mouse functional genomics, mouse mutant phenotyping, and mouse archiving.
Taken together, EUCOMMTOOLS will further advance the functional annotation of the entire mouse genome and thereby enhance the understanding of the molecular basis of disease. Furthermore, it will support drug development by SMEs and the pharmaceutical industry.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Address

Ingolstadter Landstrasse 1
85764 Neuherberg

Germany

Activity type

Research Organisations

EU Contribution

€ 4 717 398,55

Administrative Contact

Jürgen Ertel (Dr.)

Participants (10)

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GENOME RESEARCH LIMITED

United Kingdom

EU Contribution

€ 4 743 667

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 278 800,93

TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 568 800

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 359 604

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

EU Contribution

€ 360 000

UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE

Spain

EU Contribution

€ 589 165,25

MEDICAL RESEARCH COUNCIL

United Kingdom

UNIVERSIDAD DE MURCIA

Spain

EU Contribution

€ 160 038,20

MONASH UNIVERSITY

Australia

EU Contribution

€ 222 199,07

THE JACKSON LABORATORY NON PROFIT CORPORATION

United States

Project information

Grant agreement ID: 261492

Status

Closed project

  • Start date

    1 October 2010

  • End date

    30 September 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 18 169 877,15

  • EU contribution

    € 11 999 673

Coordinated by:

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

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