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Fate and effects of cytostatic pharmaceuticals in the environment and the identification of biomarkers for and improved risk assessment on environmental exposure

Objective

CytoThreat addresses the need to assess the risks of pharmaceuticals released in the environment, focusing on cytostatic drugs because they are highly hazardous compounds due to their genotoxic properties which may cause unexpected long term effects. Their release in the environment may lead to systemic ecological effects and increased cancer incidence, reduced fertility and malformations in the offspring in humans. The occurrence, distribution and fate of selected widely used cytostatics in different aquatic matrices, their acute and chronic toxicity and impact on the stability of the genetic material in a variety of aquatic organisms representing different trophic levels is addressed to provide data sets necessary for scientifically based risk assessment. Special emphasis is put on the combined effects of environmentally relevant mixtures. A combination of state-of-the art analytical chemistry, in vivo and in vitro systems, and ‘OMICS’ technologies is applied. In vivo studies with zebrafish models aim at identifying linkages between the genomic profiles, exposure conditions and adverse effects in vertebrates to identify molecular biomarkers for adverse effects of specific groups of cytostatics to be used as diagnostic markers and for predicting synergistic effects of combined exposures. Comparative in vitro genotoxicity and transcriptomic studies with zebrafish and human derived cells will provide additional information for the extrapolation of toxicological data to humans. Comparisons with the hazardous effects of other groups of pharmaceuticals will provide knowledge on the magnitude of the problem. CytoThreat will generate new knowledge on environmental and health risks of cytostatics and provide objective arguments for recommendations and regulations. Partners form 5 member states and 2 associated countries with complementary expertise in analytical chemistry, aquatic and genetic toxicology, and genomics and bioinformatics are involved.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry

Call for proposal

FP7-ENV-2010
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

NACIONALNI INSTITUT ZA BIOLOGIJO
Address
Vecna Pot 111
1000 Ljubljana
Slovenia
Activity type
Research Organisations
EU contribution
€ 609 334,65
Administrative Contact
Potocnik Franc (Mr.)

Participants (8)

INSTITUT JOZEF STEFAN
Slovenia
EU contribution
€ 407 730
Address
Jamova 39
1000 Ljubljana
Activity type
Research Organisations
Administrative Contact
Jadran Lenarcic (Prof.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 292 867,20
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christoph Zielinski (Prof.)
SZENT ISTVAN UNIVERSITY
Hungary
EU contribution
€ 224 334,40
Address
Pater Karoly Utca 1
2100 Godollo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Béla Urbányi (Dr.)
UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI
Italy
EU contribution
€ 288 563,20
Address
Viale Abramo Lincoln 5
81100 Caserta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marina Isidori (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 419 018,25
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jiménez Arroyo (Mr.)
Institut za medicinska istrazivanja i medicinu rada
Croatia
EU contribution
€ 114 122,80
Address
Ksaverska 2
10000 Zagreb
Activity type
Research Organisations
Administrative Contact
Verica Garaj Vrhovac (Prof.)
INSTITUT ZA MULTIDISCIPLINARNA ISTRAZIVANJA
Serbia
EU contribution
€ 69 243,20
Address
Kneza Viseslava 1
11030 Beograd
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Budimirka Trišić (Ms.)
RR & CO. RAZISKAVE RAZVOJ IN PRENOS ZNANJA DOO
Slovenia
EU contribution
€ 157 745,60
Address
Dunajska Cesta 20
1000 Ljubljana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ilina Hristova (Ms.)