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New Algorithms for Host Pathogen Systems Biology

Objective

SYSPATHO focuses on the development of novel and generally applicable mathematical methods and algorithms for systems biology. These methods and algorithms will be applied to study the complex interactions of hepatitis C virus (HCV), a human-pathogenic virus of high medical relevance, with its host at the systems level. Using a multidisciplinary, integrative approach, PATHOSYS will (a) develop methods to analyze and integrate a wide variety of data from wet lab experiments, databases and biological literature, (b) develop and apply machine learning tools to reconstruct and study intracellular interaction networks from experimental data, (c) develop new and improve existing algorithms and mathematical methods for bottom-up modelling, to fit models to data, and to analyze the dynamic behaviour of models (d) generate new experimental data to gain novel insights into hepatitis C virus host interactions, and (e) use the newly developed methods and data to model and analyze HCV-host interactions at the systems level. Guided by biological data, PATHOSYS focuses on the design of novel algorithms and mathematical methods for systems biology, with the aim to provide generally applicable tools to elucidate biological processes. Based on developed models and using systems analysis, PATHOSYS will elucidate virus host interactions of Hepatitis C virus at an unprecedented level. As a direct spin-off, models and analysis methods developed in PATHOSYS will lead to the identification of new candidate host cell target genes applicable for the design of novel anti-viral drugs against hepatitis C. Targeting of host cell factors will reduce the likelihood for the development of therapy resistance and increase the chance for broad-spectrum antivirals. Inclusion of two SME partners will ensure exploitation of results generated in PATHOSYS and their transfer into industrial and pharmaceutical applications, thus strengthening economy and health care system in Europe.

Call for proposal

FP7-HEALTH-2010-single-stage
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Coordinator

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Address
Seminarstrasse 2
69117 Heidelberg
Germany

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roland Eils (Prof.)
EU contribution
€ 729 378,53

Participants (10)

UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 449 552,06
Address
Im Neuenheimer Feld 672
69120 Heidelberg

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 513 600
Address
Rue De Tolbiac 101
75654 Paris

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Activity type
Research Organisations
Administrative Contact
Evelyne Bertino (Ms.)
The Establishment of the Russian Academy of Sciences Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russia
EU contribution
€ 134 131,97
Address
Lavrentyeva 10
630090 Novosibirsk

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Activity type
Research Organisations
Administrative Contact
Nikolay Kolchanov (Prof.)
PETER THE GREAT SAINT PETERSBURG POLYTECHNIC UNIVERSITY
Russia
EU contribution
€ 181 440
Address
Polytekhnicheskaya St 29
195251 Saint Petersburg

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Samsonova (Prof.)
MIDDLE EAST TECHNICAL UNIVERSITY
Türkiye
EU contribution
€ 59 825,08
Address
Dumlupinar Bulvari 1
06800 Ankara

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tolga Can (Dr.)
BAHCESEHIR UNIVERSITESI
Türkiye
EU contribution
€ 34 400,42
Address
Ciragan Cad Osmanpasa Mektebi Sok 4/6 Besiktas
34538 Istanbul

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sureyya Ozogur-Akyuz (Dr.)
SOFTWARE SYSTEMS-PREDICTING BIOLOGY OOO
Russia
EU contribution
€ 211 405,08
Address
Lavrentieva Pr. 10
630090 Novosibirsk

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vladimir Ivanisenko (Dr.)
NOVAMECHANICS LIMITED
Cyprus
EU contribution
€ 307 200
Address
Digeni Akrita 51
1070 Nicosia

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Antreas Afantitis (Dr.)
ORT BRAUDE COLLEGE
Israel
EU contribution
€ 37 872
Address
Snunit Street 51
21982 Karmiel

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Zeev(Vladimir) Vokovich (Prof.)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 283 619,61
Address
Helmholtzstrasse 10
01069 Dresden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christin Kusche (Ms.)