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Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses

Objective

RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design programme. The project aims to identify Small molecule Inhibitor Leads Versus Emerging and neglected RNA viruses (SILVER). It will focus its activities on selected medically important RNA viruses for which the development of drugs is considered essential (Dengue-, entero- and paramyxoviruses), whereas other relatively neglected and/or emerging RNA viruses will be explored to identify the most promising viral protein targets and antiviral compounds. A pipeline strategy has been developed to enable the inclusion in SILVER of viruses at all levels of existing knowledge. Targets for potential drugs include infectious virus, structurally characterised viral enzymes and other proteins. Leads for currently available antiviral drugs have been identified by screening compound libraries in virus-infected cell culture systems and in vitro assays using purified viral enzymes. Selective inhibitors of viral replication have also been (and are being) derived using detailed structural knowledge of viral proteins and structure-based drug design. Hits will be assayed using individual viral protein targets and replicative proteins in complex with viral RNA. The potential protective activity of the most potent inhibitors, that have a favourable (in vitro) ADME-tox profile, will be assessed in relevant infection models in animals. Licenses on promising compounds or compound classes will be presented to the interested pharmaceutical industry. The SILVER consortium will be well placed to play a major role in contributing to the international effort to develop strategies to improve world health.

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITE D'AIX MARSEILLE
Address
Boulevard Charles Livon 58
13284 Marseille
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 855 357,30
Administrative Contact
Céline Damon (Ms.)

Participants (23)

UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 945 400
Address
Ratzeburger Allee 160
23562 Lubeck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margret Schwab (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 993 880
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Dr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 744 609,60
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marlien Vos (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 589 400
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Leep (Mr.)
INSTITUT PASTEUR
France
EU contribution
€ 418 959,60
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 400 000
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz (Mr.)
STICHTING KATHOLIEKE UNIVERSITEIT

Participation ended

Netherlands
EU contribution
€ 144 982,72
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Van Oijen (Mr.)
RIBOXX GMBH

Participation ended

Germany
EU contribution
€ 361 720
Address
Meissner Strasse 191
01445 Radebeul
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jacques Rohayem (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 500 000
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Polik (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 350 000
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Jocelyn Mere (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 624 999,56
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jiménez Arroyo (Mr.)
Global Phasing
United Kingdom
EU contribution
€ 400 000
Address
Newton Road 43
CB2 8AL Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gerard Bricogne (Dr.)
PIKE PHARMA GMBH

Participation ended

Switzerland
EU contribution
€ 144 673,94
Address
Technoparkstrasse 1
CH-8005 Zuerich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ulrich Kessler (Dr.)
UNIVERSITAET INNSBRUCK
Austria
EU contribution
€ 375 000
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kurt Habitzel (Dr.)
UNIVERSITAET HAMBURG
Germany
EU contribution
€ 375 000
Address
Mittelweg 177
20148 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jens Bricke (Mr.)
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
China
EU contribution
€ 175 000
Address
Zu Chong Zhi Road Zhang Jiang High-tech Park 555
201203 Shanghai
Activity type
Research Organisations
Administrative Contact
Jianmei Shi (Ms.)
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
South Korea
Address
Jang Dong Yusung Gu 100
305606 Daejeon
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Youngjoo Ko (Dr.)
National Central University
Taiwan
Address
Jhongda Road 300
320 Jhongli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yu-Jin Cheng (Ms.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 543 000
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefania Varotto (Dr.)
UNIVERSITAET LEIPZIG

Participation ended

Germany
EU contribution
€ 282 674,58
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard Fuchs (Mr.)
CENTRUM VOOR INNOVATIE EN STIMULATIEVAN MEDICIJNONTWIKKELING LEUVEN VZW
Belgium
EU contribution
€ 403 000
Address
Minderbroederstraat 12
3000 Leuven
Activity type
Research Organisations
Administrative Contact
Patrick Chaltin (Dr.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 230 017,28
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Louise Van Der Kaaden (Mrs.)
FREIE UNIVERSITAET BERLIN
Germany
EU contribution
€ 142 325,42
Address
Kaiserswerther Strasse 16-18
14195 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carsten Malmwieck (Mr.)