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A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation

Objective

Preventing immunological rejection of transplanted organs without the need for long-term use of pharmacological immunosuppression is a primary objective in transplantation medicine. Reducing the need for immunosuppression would dramatically improve the outcome for transplant recipients and reduce health costs for society. The means to achieve this goal has not been realised with pharmacological or biological agents yet. Conditioning the immune response of solid organ transplant recipients towards allograft acceptance using cell-based therapies is now becoming technically feasible and clinically promising. The central focus of our proposed cooperative work programme is to produce distinct populations of haematopoietic regulatory cells and comparatively test their safety and efficacy in minimising pharmacological immunosuppression in solid organ transplantation. Preparations of regulatory T cells, macrophages and dendritic cells will be licensed for clinical manufacture in outstanding research facilities across Europe, and subsequently, these different tolerance-promoting cell types will be assessed in a single Phase I/II clinical study for safety, clinical practicality and efficacy. The therapeutic potential of these cells will be directly compared using one, single clinical protocol. In addition, we will study the tolerogenic characteristics of these regulatory cell types at in-depth molecular and functional levels. These integrative, but very focused, research plans are expected to result in the identification of the most promising regulatory cell products for further testing, and commercial exploitation: the final outcome is to identify a cell product which has genuine potential to induce operational tolerance if correctly applied in a Phase IIb clinical trial. This objective can only be accomplished by the cooperation of the most experienced researchers in this field across Europe, in alliance with SMEs devoted to cell therapy.

Field of science

  • /medical and health sciences/clinical medicine/transplantation
  • /medical and health sciences/basic medicine/immunology/immunotherapy

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

KLINIKUM DER UNIVERSITAET REGENSBURG
Address
Frans Josef Strauss Allee 11
93053 Regensburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 602 183,12
Administrative Contact
Elisabeth Geiger (Ms.)

Participants (15)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 940 001
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 023 922
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Polik (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 1 800 200
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Mario Valsecchi (Mr.)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France
EU contribution
€ 678 000
Address
Allee De L'ile Gloriette 5
44093 Nantes
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Brethet (Ms.)
MILTENYI BIOTEC GMBH
Germany
EU contribution
€ 360 000
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Apel (Dr.)
Electro Scientific Industries Europe Ltd.
United Kingdom
EU contribution
€ 293 760
Address
Avro Court, Ermine Business Park 8
PE29 6XS Huntingdon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Damon Green (Dr.)
CLINIT AG
Germany
EU contribution
€ 332 360
Address
Hornusstrasse 16
79108 Freiburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Natascha Heifer (Ms.)
PHARMATCHING GMBH

Participation ended

Germany
EU contribution
€ 32 049,28
Address
Wippertstrasse 2
79100 Freiburg Im Breisgau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sabine Kistner (Ms.)
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
EU contribution
€ 350 000
Address
Via Fiorentina 151
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cristiana Tozzi (Ms.)
THE BOARD OF REGENTS OF THE UNIVERSITY OF WISCONSIN SYSTEM
United States
EU contribution
€ 200 000
Address
Linden Drive 1220 Vanhise Hall 1860
53706 Madison Wi
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Robert Andresen (Mr.)
LOUGHBOROUGH UNIVERSITY
United Kingdom
EU contribution
€ 154 318
Address
Ashby Road
LE11 3TU Loughborough
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Louise Denniff (Ms.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 442 387,60
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kevin R. Kaier (Mr.)
THE GENERAL HOSPITAL CORPORATION
United States
EU contribution
€ 240 020
Address
Fruit Street 55
02114 Boston Ma
Activity type
Other
Administrative Contact
Anthony Cassese (Dr.)
FONDAZIONE CENTRO SAN RAFFAELE
Italy
EU contribution
€ 387 000
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Maria Rosa Pedrazzi (Dr.)