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The European Network for Translational Research in Atrial Fibrillation

The European Network for Translational Research in Atrial Fibrillation

Objective

The initiation and perpetuation of atrial fibrillation (AF) can be regarded as a complication of a progressive transformation of the structure and functional properties of the atria. This transformation is the result of complex and multiple changes at the molecular, cellular and organ levels which interact to form the basis for proarrhythmic mechanisms in AF. Numerous individual and environmental factors are probably involved in this profound transformation process in the atria. Therefore, we believe that progress in the diagnostics, prevention and treatment of AF requires highly integrative research from the molecule to bedside and from specific signaling pathways and electrophysiological mechanisms to population based studies.
A consortium was formed providing this variety of expertises and has identified central research objectives for improvements in AF prevention and therapy.
In 5 work packages focusing on basic research, new biomarkers for AF and therapeutic targets will be identified. We will study mechanisms of conduction disturbances in the atria, explore new ion channel targets for treatment of AF, identify specific alterations in the atria depending on the underlying heart disease, and evaluate beneficial effects of organ-protective compounds. Within two clinically oriented work packages the clinical application of these findings will be tested. The predictive value of diagnostic tools like serum biomarkers, 3D reconstruction of atrial conduction patterns based on high resolution body surface ECGs, and echocardiographic markers will be studied in large scale population studies. The new therapeutic targets will be explored in smaller prove-of-principle clinical trials (substrate oriented ablation, new pharmacological targets, and local gene delivery).
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Coordinator

ST GEORGE'S HOSPITAL MEDICAL SCHOOL

Address

Cranmer Terrace
Sw17 0re London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 762 762,40

Administrative Contact

Melanie Monteiro (Ms.)

Participants (19)

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UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 1 409 810,66

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

France

EU Contribution

€ 1 031 700,80

TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 278 593

CHU HOPITAUX DE BORDEAUX

France

EU Contribution

€ 1 267 000

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

EU Contribution

€ 368 494

OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG

Germany

EU Contribution

€ 904 113,80

UNIVERSITAET BERN

Switzerland

EU Contribution

€ 890 500

MEDIZINISCHE UNIVERSITAT GRAZ

Austria

EU Contribution

€ 581 516,40

ERKEM TIBBI YAYINCILIK YAZILIM GELISTIRME VE EGITIM HIZMETLERI LIMITED SIRKETI

Turkey

EU Contribution

€ 645 702,40

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 738 366,80

THE UK HEALTH & ENVIRONMENT RESEARCH INSTITUTE

United Kingdom

EU Contribution

€ 631 875

SANOFI-AVENTIS DEUTSCHLAND GMBH

Germany

EU Contribution

€ 237 849

OSYPKA AG

Germany

EU Contribution

€ 283 150

XENTION CAMBRIDGE

United Kingdom

EU Contribution

€ 290 345,60

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Germany

EU Contribution

€ 40 931,29

PHILIPPS UNIVERSITAET MARBURG

Germany

EU Contribution

€ 312 200

UNIVERSITAET GREIFSWALD

Germany

EU Contribution

€ 100 800

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

EU Contribution

€ 555 605,80

UNIVERSITAETSKLINIKUM ESSEN

Germany

EU Contribution

€ 666 016

Project information

Grant agreement ID: 261057

Status

Closed project

  • Start date

    1 November 2010

  • End date

    31 October 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 15 681 391,63

  • EU contribution

    € 11 997 332,95

Coordinated by:

ST GEORGE'S HOSPITAL MEDICAL SCHOOL

United Kingdom