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The European Network for Translational Research in Atrial Fibrillation

Objective

The initiation and perpetuation of atrial fibrillation (AF) can be regarded as a complication of a progressive transformation of the structure and functional properties of the atria. This transformation is the result of complex and multiple changes at the molecular, cellular and organ levels which interact to form the basis for proarrhythmic mechanisms in AF. Numerous individual and environmental factors are probably involved in this profound transformation process in the atria. Therefore, we believe that progress in the diagnostics, prevention and treatment of AF requires highly integrative research from the molecule to bedside and from specific signaling pathways and electrophysiological mechanisms to population based studies.
A consortium was formed providing this variety of expertises and has identified central research objectives for improvements in AF prevention and therapy.
In 5 work packages focusing on basic research, new biomarkers for AF and therapeutic targets will be identified. We will study mechanisms of conduction disturbances in the atria, explore new ion channel targets for treatment of AF, identify specific alterations in the atria depending on the underlying heart disease, and evaluate beneficial effects of organ-protective compounds. Within two clinically oriented work packages the clinical application of these findings will be tested. The predictive value of diagnostic tools like serum biomarkers, 3D reconstruction of atrial conduction patterns based on high resolution body surface ECGs, and echocardiographic markers will be studied in large scale population studies. The new therapeutic targets will be explored in smaller prove-of-principle clinical trials (substrate oriented ablation, new pharmacological targets, and local gene delivery).

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Address
Cranmer Terrace
SW17 0RE London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 762 762,40
Administrative Contact
Melanie Monteiro (Ms.)

Participants (19)

UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 1 409 810,66
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrich Schotten (Dr.)
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
France
EU contribution
€ 1 031 700,80
Address
Place Jussieu 4
75252 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Wiest (Mr.)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 278 593
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Brenner (Ms.)
CHU HOPITAUX DE BORDEAUX
France
EU contribution
€ 1 267 000
Address
Rue Dubernat 12
33404 Talence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jean-Jacques Jalibert (Mr.)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 368 494
Address
Schlossplatz 2
48149 Munster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Oliver Panzer (Mr.)
OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Germany
EU contribution
€ 904 113,80
Address
Universitaetsplatz 2
39106 Magdeburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sigmar Beust (Dr.)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 890 500
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephan Rohr (Prof.)
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 581 516,40
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Burkert Pieske (Prof.)
ERKEM TIBBI YAYINCILIK YAZILIM GELISTIRME VE EGITIM HIZMETLERI LIMITED SIRKETI
Turkey
EU contribution
€ 645 702,40
Address
Cinnah Caddesi 98/4
06690 Ankara
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mehmet Ali Oto (Prof.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 738 366,80
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Pialek (Ms.)
THE UK HEALTH & ENVIRONMENT RESEARCH INSTITUTE LIMITED
United Kingdom
EU contribution
€ 631 875
Address
Pera Business Park Nottingham Road
LE13 0PB Melton Mowbray
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lydia Lepecuchel (Dr.)
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
EU contribution
€ 237 849
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bernd Rosenstock (Dr.)
OSYPKA AG
Germany
EU contribution
€ 283 150
Address
Earl H Wood Strasse 1
79618 Rheinfelden Baden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thorsten Gottsche (Mr.)
XENTION LTD
United Kingdom
EU contribution
€ 290 345,60
Address
Iconix Park, London Road, Pampisford
CB22 3EG Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Madge (Dr.)
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Participation ended

Germany
EU contribution
€ 40 931,29
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dobromir Dobrev (Prof.)
PHILIPPS UNIVERSITAET MARBURG
Germany
EU contribution
€ 312 200
Address
Biegenstrasse 10
35037 Marburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sandra Basenau (Ms.)
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 100 800
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Voelker (Dr.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 555 605,80
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 666 016
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sebastian George (Mr.)