Objectif This grant application is formulated to explore the biological role of the Cullin7 (CUL7) E3 ubiquitin ligase in insulin signaling and its implication for diabetes. My previous work led to the identification of insulin receptor substrate 1 (IRS-1) as the proteolytic target of the CUL7 E3 ligase and uncovered CUL7 as a novel regulator of insulin signaling. Based on these observations, I will employ experimental strategies as outlined in this proposal to delineate CUL7`s role for the cellular insulin response and its contribution to insulin resistance and type 2 diabetes. Champ scientifique medical and health sciencesclinical medicineendocrinologydiabetes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Appel à propositions FP7-PEOPLE-2009-RG Voir d’autres projets de cet appel Régime de financement MC-IRG - International Re-integration Grants (IRG) Coordinateur TECHNISCHE UNIVERSITAET MUENCHEN Contribution de l’UE € 100 000,00 Adresse Arcisstrasse 21 80333 Muenchen Allemagne Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Ulrike Ronchetti (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
