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Mechanisms of the Development of ALLergy

Mechanisms of the Development of ALLergy

Objective

Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational approach is needed. MeDALL includes experts in allergy, epidemiology, genetics, immunology, biology, animal models, biochemistry and systems biology combining strengths of ongoing EU projects. Classical phenotypes (expert-based) and novel phenotypes of allergy (hypothesis-free statistical modelling) are compared. Population-based data are collected from a cross-sectional study (Karelia) and existing birth-cohorts followed using a common protocol. IgE to foods and inhalants are tested using component-resolved diagnosis across Europe in populations. Biomarker profiles (“fingerprints”) are extensively assessed using epigenetics, targeted proteomics and unbiased transcriptomics in a subsample of the study population. Those associated with allergic phenotypes are validated in large study populations. Relevant fingerprints are combined into network biomarker phenotype “handprints” using a systems biology approach and validated in a sufficiently powered sample. Animal studies and in vitro human immunology reinforce the validation. This information coupled with classical and novel phenotypes characterize environmental protective and susceptibility factors of allergy and risk groups. Results are fitted into new integrative complex mathematical models to establish suitable biomarkers for early diagnosis, prevention and targets for therapy of allergy-associated diseases such as asthma and atopic dermatitis. Ethics and gender are considered. MeDALL aims at improving health of European citizens, Europe competitiveness and innovative capacity while addressing global health issues.
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Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris

France

Activity type

Research Organisations

EU Contribution

€ 658 597,20

Administrative Contact

Audrey Laurent (Ms.)

Participants (22)

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FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

Spain

EU Contribution

€ 1 493 456

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 517 553

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 1 380 930

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 1 896 840

UNIVERSITEIT GENT

Belgium

EU Contribution

€ 613 643

HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ

Finland

EU Contribution

€ 183 086,40

UNIVERSYTET MEDYCZNY W LODZI.

Poland

EU Contribution

€ 59 399,60

UNIVERSITETET I OSLO

Norway

EU Contribution

€ 287 095

MEDIZINISCHE UNIVERSITAET WIEN

Austria

EU Contribution

€ 746 461,60

SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS

Switzerland

EU Contribution

€ 729 630,40

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 341 550

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 568 260,25

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 292 051

INSERM TRANSFERT SA

France

EU Contribution

€ 823 681

BIOMAX INFORMATICS AG

Germany

EU Contribution

€ 597 365

onmedic Networks, S.L

Spain

EU Contribution

€ 194 153,40

BIOMAY AG

Austria

EU Contribution

€ 49 500

BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST

United Kingdom

EU Contribution

€ 249 846,30

Arizona Board of Regents

United States

EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING

Belgium

EU Contribution

€ 77 840,25

ODENSE UNIVERSITETSHOSPITAL

Denmark

EU Contribution

€ 55 000

AZIENDA SANITARIA LOCALE ROMA

Italy

EU Contribution

€ 174 999,60

Project information

Grant agreement ID: 261357

Status

Closed project

  • Start date

    1 December 2010

  • End date

    31 May 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 15 659 041,05

  • EU contribution

    € 11 990 939

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France