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Mechanisms of the Development of ALLergy

Objective

Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational approach is needed. MeDALL includes experts in allergy, epidemiology, genetics, immunology, biology, animal models, biochemistry and systems biology combining strengths of ongoing EU projects. Classical phenotypes (expert-based) and novel phenotypes of allergy (hypothesis-free statistical modelling) are compared. Population-based data are collected from a cross-sectional study (Karelia) and existing birth-cohorts followed using a common protocol. IgE to foods and inhalants are tested using component-resolved diagnosis across Europe in populations. Biomarker profiles (“fingerprints”) are extensively assessed using epigenetics, targeted proteomics and unbiased transcriptomics in a subsample of the study population. Those associated with allergic phenotypes are validated in large study populations. Relevant fingerprints are combined into network biomarker phenotype “handprints” using a systems biology approach and validated in a sufficiently powered sample. Animal studies and in vitro human immunology reinforce the validation. This information coupled with classical and novel phenotypes characterize environmental protective and susceptibility factors of allergy and risk groups. Results are fitted into new integrative complex mathematical models to establish suitable biomarkers for early diagnosis, prevention and targets for therapy of allergy-associated diseases such as asthma and atopic dermatitis. Ethics and gender are considered. MeDALL aims at improving health of European citizens, Europe competitiveness and innovative capacity while addressing global health issues.

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 658 597,20
Administrative Contact
Audrey Laurent (Ms.)

Participants (22)

FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL
Spain
EU contribution
€ 1 493 456
Address
Calle Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Gemma Perello (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 517 553
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Prof.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 1 380 930
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Ludovic Hamon (Mr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 1 896 840
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
J.M. Van Apeldoorn (Mr.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 613 643
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margo Baele (Dr.)
HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ
Finland
EU contribution
€ 183 086,40
Address
Stenbackinkatu 9
00029 Helsinki
Activity type
Research Organisations
Administrative Contact
Merja Takala (Ms.)
UNIVERSYTET MEDYCZNY W LODZI.
Poland
EU contribution
€ 59 399,60
Address
Al. Kosciuszki, 4
90419 Lodz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aneta Andrzejczyk (Ms.)
UNIVERSITETET I OSLO
Norway
EU contribution
€ 287 095
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Randi Stene (Ms.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 746 461,60
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rudolf Valenta (Prof.)
SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS
Switzerland
EU contribution
€ 729 630,40
Address
Promenade 35
7270 Davos Platz
Activity type
Research Organisations
Administrative Contact
Daniela Bert (Ms.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 341 550
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Miles Davies (Dr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 568 260,25
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 292 051
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monique Van Der Hoek (Ms.)
INSERM TRANSFERT SA
France
EU contribution
€ 823 681
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)
BIOMAX INFORMATICS AG
Germany
EU contribution
€ 597 365
Address
Robert Koch Strasse 2
82152 Planegg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dieter Maier (Dr.)
onmedic Networks, S.L
Spain
EU contribution
€ 194 153,40
Address
Balmes 30
08007 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cristina Sanchez Garrido (Ms.)
BIOMAY AG
Austria
EU contribution
€ 49 500
Address
Lazarettgasse 19
1090 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Angela Neubaeur (Dr.)
BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 249 846,30
Address
Duckworth Lane
BD9 6RJ Bradford
Activity type
Research Organisations
Administrative Contact
Alec Cowell (Mr.)
ARIZONA BOARD OF REGENTS
United States
Address
660 S Mill Avenue Centerpoint 312
85281 Tempe
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elizabeth Beckett-Firmage (Ms.)
EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING
Belgium
EU contribution
€ 77 840,25
Address
Rue Du Congrès 35
1000 Brussels
Activity type
Other
Administrative Contact
Susanna Palkonen (Ms.)
REGION SYDDANMARK
Denmark
EU contribution
€ 55 000
Address
Damhaven 12
7100 Vejle
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Annemette Hedegaard (Ms.)
AZIENDA SANITARIA LOCALE ROMA
Italy
EU contribution
€ 174 999,60
Address
Borgo Santo Spirito 3
00198 Roma
Activity type
Research Organisations
Administrative Contact
Mirella Salatino (Ms.)