Objective Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational approach is needed. MeDALL includes experts in allergy, epidemiology, genetics, immunology, biology, animal models, biochemistry and systems biology combining strengths of ongoing EU projects. Classical phenotypes (expert-based) and novel phenotypes of allergy (hypothesis-free statistical modelling) are compared. Population-based data are collected from a cross-sectional study (Karelia) and existing birth-cohorts followed using a common protocol. IgE to foods and inhalants are tested using component-resolved diagnosis across Europe in populations. Biomarker profiles (“fingerprints”) are extensively assessed using epigenetics, targeted proteomics and unbiased transcriptomics in a subsample of the study population. Those associated with allergic phenotypes are validated in large study populations. Relevant fingerprints are combined into network biomarker phenotype “handprints” using a systems biology approach and validated in a sufficiently powered sample. Animal studies and in vitro human immunology reinforce the validation. This information coupled with classical and novel phenotypes characterize environmental protective and susceptibility factors of allergy and risk groups. Results are fitted into new integrative complex mathematical models to establish suitable biomarkers for early diagnosis, prevention and targets for therapy of allergy-associated diseases such as asthma and atopic dermatitis. Ethics and gender are considered. MeDALL aims at improving health of European citizens, Europe competitiveness and innovative capacity while addressing global health issues. Fields of science medical and health sciencesclinical medicinepneumologyasthmamedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineallergologynatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.5-1 - Investigation of the mechanisms of initiation of allergic response, genetic predisposition, biomarkers and identification of targets for therapy. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE EU contribution € 658 597,20 Address Rue de tolbiac 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Audrey Laurent (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (22) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL Spain EU contribution € 1 493 456,00 Address Calle doctor aiguader 88 08003 Barcelona See on map Activity type Research Organisations Administrative Contact Gemma Perello (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 517 553,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fräßdorf (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 1 380 930,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Ludovic Hamon (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands EU contribution € 1 896 840,00 Address Hanzeplein 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Administrative Contact J.M. Van Apeldoorn (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT GENT Belgium EU contribution € 613 643,00 Address Sint pietersnieuwstraat 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Administrative Contact Margo Baele (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HUS-YHTYMA Finland EU contribution € 183 086,40 Address Stenbackinkatu 9 00029 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Administrative Contact Merja Takala (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSYTET MEDYCZNY W LODZI. Poland EU contribution € 59 399,60 Address Al. kosciuszki, 4 90419 Lodz See on map Region Makroregion centralny Łódzkie Łódzki Activity type Higher or Secondary Education Establishments Administrative Contact Aneta Andrzejczyk (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITETET I OSLO Norway EU contribution € 287 095,00 Address Problemveien 5-7 0313 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Higher or Secondary Education Establishments Administrative Contact Randi Stene (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 746 461,60 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Rudolf Valenta (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS Switzerland EU contribution € 729 630,40 Address Obere strasse 22 7270 Davos platz See on map Region Schweiz/Suisse/Svizzera Ostschweiz Graubünden / Grigioni / Grischun Activity type Research Organisations Administrative Contact Daniela Bert (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 341 550,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Miles Davies (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Germany EU contribution € 568 260,25 Address Ingolstadter landstrasse 1 85764 Neuherberg See on map Region Bayern Oberbayern München, Landkreis Activity type Research Organisations Administrative Contact Juergen Ertel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT UTRECHT Netherlands EU contribution € 292 051,00 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Monique Van Der Hoek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSERM TRANSFERT SA France EU contribution € 823 681,00 Address 10 rue d'oradour-sur-glane - parisante campus 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Louis Jammayrac (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOMAX INFORMATICS AG Germany EU contribution € 597 365,00 Address Robert koch strasse 2 82152 Steinkirchen See on map Region Bayern Oberbayern München, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Dieter Maier (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data onmedic Networks, S.L Spain EU contribution € 194 153,40 Address Balmes 30 08007 Barcelona See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Cristina Sanchez Garrido (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOMAY AG Austria EU contribution € 49 500,00 Address Lazarettgasse 19 1090 Wien See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Angela Neubaeur (Dr.) Links Contact the organisation Opens in new window Total cost No data BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST United Kingdom EU contribution € 249 846,30 Address Duckworth lane BD9 6RJ Bradford See on map Region Yorkshire and the Humber West Yorkshire Bradford Activity type Research Organisations Administrative Contact Alec Cowell (Mr.) Links Contact the organisation Opens in new window Total cost No data ARIZONA BOARD OF REGENTS United States EU contribution No data Address 660 s mill avenue centerpoint 312 85281 Tempe See on map Activity type Higher or Secondary Education Establishments Administrative Contact Elizabeth Beckett-Firmage (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING Sweden EU contribution € 77 840,25 Address Rue du congres 35 1000 Bruxelles See on map Activity type Other Administrative Contact Susanna Palkonen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ODENSE UNIVERSITETSHOSPITAL Denmark EU contribution € 55 000,00 Address Sdr. boulevard 29 5000 Odense See on map Activity type Research Organisations Administrative Contact Annemette Hedegaard (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AZIENDA SANITARIA LOCALE ROMA Italy EU contribution € 174 999,60 Address Borgo santo spirito 3 00198 Roma See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Mirella Salatino (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data