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Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases

Objective

Chronic inflammatory diseases associated with allergy, including asthma and rhinitis, constitute a major and continuously growing public health concern for Europe. However, the causative factors and mechanisms converting a physiological inflammatory reaction to a chronic response triggering allergic disease remain elusive.
Viral infections, particularly those caused by human rhinoviruses (RV) are the most frequent triggers of acute asthma exacerbations. RV infections have more recently been associated with asthma initiation; there is evidence suggesting that such infections may also contribute to respiratory allergy persistence.
The strategic aims of PreDicta are to evaluate the hypothesis that repeated infections reprogram the immune system towards a persistent inflammatory pattern leading to respiratory allergies by (i) dissecting the molecular and cellular mechanisms involved in the lack of resolution of inflammation in the context of a human disease, (ii) identifying specific infectious agents and underlying altered host-pathogen interactions, and develop relevant prognostic and therapeutic strategies. PreDicta follows three interconnected workflows: models, mechanisms and translational output. Models include a longitudinal cohort in children, mouse models of repeated virus infection, primary epithelial cultures from patients, viral-bacterial interaction models, and models of epithelial-T-cell-dendritic cell interactions. These will be used to look into disease persistence, inflammation patterns, dysbiosis, immune regulation and resolution of inflammation. Translational outputs include prognostic use of subtype-specific antiviral antibodies, DNAZymes for therapeutic use and delivery technologies targeted to the bronchial epithelium.
This interdisciplinary Consortium with strong track record, unique resources and strong translational focus, aims to produce new knowledge and technologies that can rapidly and effectively reach clinical care.

Call for proposal

FP7-HEALTH-2010-single-stage
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Address
6 Christou Lada Str
10561 Athina
Greece
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 560 077
Administrative Contact
Efstathia Kafentzi (Ms.)

Participants (12)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 080 780
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 644 400
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rudolf Valenta (Prof.)
SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS
Switzerland
EU contribution
€ 640 955
Address
Promenade 35
7270 Davos Platz
Activity type
Research Organisations
Administrative Contact
Daniela Bert (Ms.)
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
EU contribution
€ 582 972
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
Administrative Contact
Dimitris Raptis (Mr.)
UNIVERSYTET MEDYCZNY W LODZI.
Poland
EU contribution
€ 249 910
Address
Al. Kosciuszki, 4
90419 Lodz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aneta Andrzejczyk (Ms.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 589 020
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Vandepitte (Ms.)
PHILIPPS UNIVERSITAET MARBURG
Germany
EU contribution
€ 489 180
Address
Biegenstrasse 10
35037 Marburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Maarten Veldman (Dr.)
TURUN YLIOPISTO
Finland
EU contribution
€ 210 420
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eliisa Särkilahti (Dr.)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 403 676
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Herrmann (Ms.)
BIOMAY AG
Austria
EU contribution
€ 77 250
Address
Lazarettgasse 19
1090 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Angela Neubauer (Dr.)
INSERM TRANSFERT SA
France
EU contribution
€ 300 000
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)
VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 162 960
Address
Kiinamyllynkatu 4-8
20520 Turku
Activity type
Research Organisations
Administrative Contact
Jari-Pekka Tuominen (Mr.)