Skip to main content

The MEtabolic Road to DIAstolic Heart Failure

Objective

More than 50% of heart failure (HF) patients present without a major deficit of left ventricular (LV) systolic function and are presumed to suffer from diastolic HF (DHF) because diastolic LV distensibility is usually impaired in these patients. The vast majority (~80%) of DHF patients is exposed to metabolic risk factors. The MEDIA consortium therefore investigates:1) how metabolic derangements contribute to DHF; 2) how diagnostic algorithms for DHF can be improved by assessing metabolic risk; 3) how correction of metabolic risk can open new therapeutic perspectives for DHF.Hereto MEDIA will: 1) Expose animal models of DHF to intense metabolic risk in order to accelerate DHF development. 2) Perform mechanistic studies in cardiomyocytes derived from DHF animal models or from DHF patients. Because of the acquired nature of metabolic risk, these studies will focus on posttranslational modifications of proteins and on epigenetic control of hypertrophy development. Their relevance for global LV function will also be appraised; 3) Perform mechanistic studies on myocardial collagen synthesis, which is enhanced by metabolic risk, and execute a phase II trial in DHF with cardiac specific antifibrotic therapy; 4) Explore the use of biomarkers as premorbid identifiers of DHF in existing cohorts of patients exposed to metabolic risk; 5) Prospectively test biomarkers and arterial stiffening, which is accelerated by metabolic risk, for their diagnostic potential in a large DHF cohort; 6) Assess myocardial metabolic substrate preference with modern imaging techniques and improve diastolic LV dysfunction through modified substrate utilization in a phase II trial.
Expected results of MEDIA are: 1) Identification of metabolic risk-related mechanisms as therapeutic targets; 2) Improved diagnostic algorithms through inclusion of biomarkers and arterial stiffness tests. 3) Novel treatments consisting of modified myocardial substrate utilization and myocardial antifibrotic therapy.

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Coordinator

STICHTING VUMC
Address
De Boelelaan 1117
1081 HV Amsterdam
Netherlands

See on map

Activity type
Research Organisations
Administrative Contact
Philippe Seignette (Mr.)

Participants (21)

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 497 400
Address
Dr Molewaterplein 40
3015 GD Rotterdam

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jacobus Maria Kerkvliet (Mr.)
RUHR-UNIVERSITAET BOCHUM
Germany
EU contribution
€ 916 945,26
Address
Universitaetsstrasse 150
44801 Bochum

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wolfgang Linke (Prof.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 772 260
Address
Chariteplatz 1
10117 Berlin

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fraessdorf (Ms.)
UNIVERSIDADE DO PORTO
Portugal
EU contribution
€ 811 718,88
Address
Praca Gomes Teixeira
4099-002 Porto

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Manuel Sobral-Torres (Dr.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 554 710,88
Address
Prinsstraat 13
2000 Antwerpen

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Mr.)
FONDATION TRANSPLANTATION
France
EU contribution
€ 975 270,94
Address
Rue De La Brot 4
21850 St Apollinaire

See on map

Activity type
Research Organisations
Administrative Contact
Stephanie Grojean (Dr.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 1 053 750
Address
Minderbroedersberg 4
6200 MD Maastricht

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rob Vanderzander (Dr.)
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
EU contribution
€ 788 550,50
Address
Avenida De Pio Xii 55
31008 Pamplona

See on map

Activity type
Research Organisations
Administrative Contact
Andrew Solomon (Dr.)
UNIVERSITETET I OSLO
Norway
EU contribution
€ 500 146,80
Address
Problemveien 5-7
0313 Oslo

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Randi Stene (Ms.)
DEBRECENI EGYETEM
Hungary
EU contribution
€ 499 783,03
Address
Egyetem Ter 1
4032 Debrecen

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Zoltán Papp (Dr.)
UNIVERSITA DEGLI STUDI DI BRESCIA
Italy
EU contribution
€ 496 231,26
Address
Piazza Mercato 15
25121 Brescia

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Livio Dei Cas (Prof.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 530 187,40
Address
Newport Road 30 36
CF24 0DE Cardiff

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nick Bodycombe (Mr.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
EU contribution
€ 532 471,92
Address
Duomo 6
13100 Vercelli

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Cellerino (Dr.)
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 524 515,90
Address
Piazza Dell Universita 1
06123 Perugia

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Bistoni (Prof.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 539 161,20
Address
Belfield
4 Dublin

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal Doolan (Mr.)
DIGNA BIOTECH, S.L
Spain
EU contribution
€ 52 166,03
Address
Avenida Pio Xii 22 Officina 2
31008 Pamplona

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juan Ruiz (Dr.)
PLURI BIOTECH LTD
Israel
EU contribution
€ 92 955
Address
Matam Industrial Park Bldg 20
31905 Haifa

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frida Grynspan (Dr.)
OXI GEN LAB SRL

Participation ended

Italy
Address
Via Marconi 11/a
25128 Brescia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marco Veronesi (Dr.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 127 800
Address
Im Neuenheimer Feld 672
69120 Heidelberg

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz (Mr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Philip Seignette (Mr.)
STICHTING VU

Participation ended

Netherlands
EU contribution
€ 1 705 696
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Philip Seignette (Mr.)