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Infectious triggers of chronic autoimmunity

Infectious triggers of chronic autoimmunity

Objective

This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the induction and perpetuation of severe systemic autoimmune disease with the ultimate object of identifying new therapeutic strategies based on knowledge of pathogenesis.
Our strategy will systematically analyse the complex and diverse processes involved in a “model” human disease: - Anti-neutrophil cytoplasmic antibody (ANCA) associated systemic vasculitis (AAV). AAV is ideally suited because it is known to be caused by autoantibodies of defined specificity and second because it is strongly linked to infection to infection. INTRICATE will use mouse models to answer the specific question whether infection with clinically relevant bacteria induces autoimmune disease in transgenic mice that express the human autoantigen. The use of novel high-throughput antigen array technology in well-characterized patient cohorts and analysis of microbial and host specific mechanisms combined with genome wide association study (GWAS) will determine whether dysbiosis or infection with specific microorganisms triggers the induction or re-activation of AAV. Unraveling the pathogenic processes that are responsible for this chronic autoimmune disease and the knowledge gained will lead to the development of novel preventive and therapeutic strategies.
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Coordinator

MEDIZINISCHE UNIVERSITAET WIEN

Address

Spitalgasse 23
1090 Wien

Austria

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 954 078

Administrative Contact

Dontscho Kerjaschki (Prof.)

Participants (11)

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MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 199 873,56

UNIVERSITAETSKLINIKUM BONN

Germany

EU Contribution

€ 428 940

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 422 740

Mayo Clinic

United States

EU Contribution

€ 599 849

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 766 094

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 523 876

BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

United States

EU Contribution

€ 522 278

EMC MICROCOLLECTIONS GMBH

Germany

EU Contribution

€ 478 600

Hycult biotechnology bv

Netherlands

EU Contribution

€ 178 200

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Germany

EU Contribution

€ 422 469

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 468 088,44

Project information

Grant agreement ID: 261382

Status

Closed project

  • Start date

    1 November 2010

  • End date

    30 April 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 764 663,80

  • EU contribution

    € 5 965 086

Coordinated by:

MEDIZINISCHE UNIVERSITAET WIEN

Austria