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High resolution tools to understand the functional role of protein intrinsic disorder

Objective

Recent evidence shows that a large share of proteins gain functional advantages by remaining natively unstructured, either completely or partially, thus challenging well-established concepts in structural biology. In order to characterize the highly dynamical nature of such “intrinsically disordered proteins”, and follow their (possible) reorganization by interacting with partners, new integrated multidisciplinary approaches combining a variety of experimental and computational techniques are needed. Our proposal is focused on NMR spectroscopy, since this technique offers an arsenal of effective tools for the study of the structural and dynamical properties of disordered states of proteins at atomic resolution in systems as complex as whole cells. In order to achieve the full potential of this approach, however, current methods should be further developed and properly interfaced with other complementary techniques. The purpose of our network is thus to establish a framework to train a new generation of young researchers and help them develop the necessary skills to successfully respond to the challenges associated with the elucidation of the functional role of intrinsically disordered protein states. If achieved, this goal will provide us with a more quantitative understanding of the biochemical processes at the basis of life and have a significant impact in biomedical research and in the design of new drugs.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/molecular biology/structural biology

Call for proposal

FP7-PEOPLE-2010-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE
Address
Piazza San Marco 4
50121 Firenze
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 580 132,93
Administrative Contact
Isabella Caterina Felli (Prof.)

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 529 875,92
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Jean-Xavier Boucherle (Dr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 477 452,04
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Phil Irving (Dr.)
VIB VZW
Belgium
EU contribution
€ 469 476,33
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 561 771,18
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr.)
BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
EU contribution
€ 331 464,31
Address
Aulich Lajos Utca 26
2100 Goedoello
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andras Dinnyes (Dr.)
GIOTTO BIOTECH SRL
Italy
EU contribution
€ 258 621,83
Address
Via Madonna Del Piano 6
50019 Sesto Fiorentino Fi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simona Fedi (Ms.)
Bruker Biospin AG
Switzerland
EU contribution
€ 223 037,41
Address
Industriestrasse 26
8117 Faellanden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rainer Kuemmerle (Dr.)
MAGYAR TUDOMANYOS AKADEMIA SZEGEDI BIOLOGIAI KOZPONT ENZIMOLOGIAI INTEZET

Participation ended

Hungary
Address
Karolina Ut 29-31
1113 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Tompa (Dr.)
PROTERA SRL

Participation ended

Italy
Address
Viale Delle Idee 22
50019 Sesto Fiorentino (Fi)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mario Lorenzoni (Dr.)