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Pharmacodynamic Approaches to Demonstration of Disease-Modification in Huntington’s Disease by SEN0014196

Objective

The Consortium will undertake clinical research activities aimed at ascertaining feasibility of a range of pharmacodynamic readouts for use in the clinical development of SEN0014196 to demonstrate the disease-modifying properties of the compound in Huntington’s Disease. SEN0014196 is a novel and selective SirT1 inhibitor, currently in Phase I clinical development, and enjoys Orphan Status in the EU as of September 2, 2009. A multi-factorial approach will be used, including assessment of both novel and compound-specific measures of molecular action as well as previously identified predictors of disease progression. The translational approaches addressed by this project are instrumental in the progression of SEN0014196 to clinical proof-of-concept and, if successful, will play a pivotal role in patient stratification and outcomes research. The Consortium will comprise four partners, all with a proven track-record in Research and Development in the Huntington’s Disease area. All Partners are based within the EU.

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

SIENA BIOTECH SPA
Address
Via Fiorentina 1
53100 Siena
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 540 673,73
Administrative Contact
Enrica Diodato (Dr.)

Participants (4)

UNIVERSITAET ULM
Germany
EU contribution
€ 1 104 681,20
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
University College London
United Kingdom
EU contribution
€ 2 001 045,20
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
KCR SA
Poland
EU contribution
€ 916 669,87
Address
Ul. Postepu 6
02 676 Warszawa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Agnieszka Felicjańczuk (Dr.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 253 243,60
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dawn Carpenter (Ms.)