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Evaluation and impact of screening and treatment approaches for the prevention of cervical neoplasia in HIV-positive women in Burkina Faso and South Africa: HPV in Africa Research Partnership

Objective

The proposal's overall aim is to improve cervical cancer prevention programs for HIV–infected women in Africa, by evaluating the effectiveness and cost-effectiveness of alternative screening strategies, and by developing algorithms leading to earlier detection and management of cervical cancer in these high-risk populations.

The proposal's hypotheses are that: i) the use of simplified point of care diagnostic tests to detect high-risk (HR) HPV DNA , never before evaluated in Africa, alone or combination with other tests in various triage strategies has the potential to improve the coverage of cervical cancer screening in high-risk populations, and that it will prove a cost-effective cervical cancer prevention intervention in the long term; and ii) immune restoration and control of HIV replication through highly active antiretroviral therapy (HAART) or HAART initiation improves clearance of HPV infection among high-risk (HR)-HPV infected women, therefore slowing the development or progression of cervical precursor lesions. These findings may suggest that varying strategies or frequencies of screening may be required for women on HAART or not.

The study will enroll 1200 HIV positive women (half on HAART or about to start HAART; and half with high CD4 count>350) in Burkina Faso and South Africa in a cross-sectional evaluation of cervical cancer screening strategies, from which about 1100 HIV-infected women without CIN2+ will be followed at one year to detect incident CIN2+ and persistence, incidence and clearance of HR HPV. A costing and modelling studies will determine the cost-effectiveness of triage strategies targeting HIV+ women.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-AFRICA-2010
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
Address
Keppel Street
WC1E 7HT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 694 994
Administrative Contact
Frankie Liew (Mr.)

Participants (3)

UNIVERSITY OF THE WITWATERSRAND JOHANNESBURG
South Africa
EU contribution
€ 1 237 360
Address
Jan Smuts Avenue 1
2001 Johannesburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Violet Parker (Ms.)
CENTRE DE RECHERCHE INTERNATIONALE POUR LA SANTE
Burkina Faso
EU contribution
€ 621 201
Address
Avenue De L'universite 221 Secteur 13 Zogona
09 Ouagadougou
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aminata Karambiri (Ms.)
UNIVERSITE MONTPELLIER I.
France
EU contribution
€ 446 445
Address
Bd Henri Iv,5
34060 Montpellier
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cara Chan Manville (Ms.)