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Syndromic approach to Neglected Infectious Diseases (NID) at primary health care level: an international collaboration on integrated diagnostic-treatment platforms

Objective

Neglected Infectious Diseases (NID) such as trypanosomiasis, leishmaniasis, schistosomiasis and soil-transmitted helminthiasis receive less than 5% of the global investment for tropical diseases research. Clinical praxis in disease-endemic countries (DEC) is rarely evidence based and does not make use of the latest innovations in diagnostic technology. NID–related research on diagnostics is particularly underfunded, and diagnostic tools are lacking for a number of NID.
The aim of this proposal is to bridge the gap between existing technological innovation in diagnostics and clinical care practice for NID in resource-poor settings. The specific objectives are to develop simple, cost-effective diagnosis-treatment algorithms for three NID-related clinical syndromes: the persistent fever, the neurological and the digestive syndromes. Evidence-based algorithms for the primary care level will be designed with a patient-centred approach, following guidance from DEC stakeholders and making the best possible use of existing assays and treatments. Relevant diagnostic technology and diagnostic platforms will be introduced according to the specific epidemiological contexts in Africa and South-Asia.
The research consortium brings together a network of clinical epidemiologists, a diagnostics development group, several partners from academia and SMEs. The consortium further includes workpackages on reference laboratory, economic evaluation, quality assurance and translation to policy.
By developing accurate and affordable diagnostic platforms and by optimizing diagnostic-treatment algorithms, this project will rationalise treatment use, circumvent progression to severe presentations and thereby reduce NID morbidity/mortality and hinder the emergence of resistances. The project will result in two main deliverables: policy recommendation for health authorities in DEC, and a series of innovative diagnostic platforms.

Field of science

  • /medical and health sciences/health sciences/infectious disease
  • /medical and health sciences/health sciences/tropical medicine

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Address
Nationalestraat 155
2000 Antwerpen
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 070 522,60
Administrative Contact
Eva Mostmans (Ms.)

Participants (12)

INSERM TRANSFERT SA
France
EU contribution
€ 288 329
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Natacha Edme (Dr.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 532 000
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emilie Alirol (Dr.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 676 200
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jana Sabinovska (Ms.)
INSTITUT NATIONAL DE RECHERCHE BIOMEDICALE DU ZAIRE
Democratic Republic of the Congo
EU contribution
€ 242 654
Address
Avenue De La Democratie
1197 Kinshasa Gombe
Activity type
Research Organisations
Administrative Contact
Franck Lionzo Bilebile (Dr.)
GADJAH MADA UNIVERSITY
Indonesia
EU contribution
€ 287 000
Address
Bulaksumur
55281 Yogyakarta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wenny Widyastuti (Ms.)
INSTITUT NATIONAL DE RECHERCHE EN SANTE PUBLIQUE INRSP
Mali
EU contribution
€ 286 463,90
Address
Route De Koulikoro Avenue Amilcar Cabral 52
Bamako
Activity type
Research Organisations
Administrative Contact
Moussa Sacko (Dr.)
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT
Switzerland
EU contribution
€ 295 000
Address
Socinstrasse 57
CH-4002 Basel
Activity type
Research Organisations
Administrative Contact
Jürg Utzinger (Prof.)
SITA RAM MEMORIAL TRUST
India
EU contribution
€ 210 000
Address
Rambag Road, Sita Ram Memorial Trust, Unit Kala Azar Medical Research Centre
842001 Muzaffarpur
Activity type
Research Organisations
Administrative Contact
Shyam Sundar (Prof.)
BP KOIRALA INSTITUTE OF HEALTH SCIENCES
Nepal
EU contribution
€ 336 000
Address
Ghopa
Dharan
Activity type
Research Organisations
Administrative Contact
Nand Kumar Thapa (Mr.)
University of Khartoum
Sudan
EU contribution
€ 251 329,70
Address
University Of Khartoum
11115 Khartoum
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sayda El Safi (Prof.)
Sihanouk Hospital Corporation
United States
EU contribution
€ 165 500,80
Address
W. Lancaster Ave 353
19087 Wayne
Activity type
Research Organisations
Administrative Contact
Shelly Malhotra (Ms.)
CORIS BIOCONCEPT SPRL
Belgium
EU contribution
€ 359 000
Address
Rue Jean Sonet 4A Parc Scientifique Crealys Les Isnes
5032 Gembloux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marc Visser (Mr.)