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Suicidality: Treatment Occurring in Paediatrics

Objective

The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Related Suicidality (PRS) in terms of phenomenology, clinical expression and time course, and may vary between children and adults. Unlike PRS, the time-course of MRS may be associated with possible differences in drug pharmacokinetics; abrupt onset; absence of suicidality prior to start of medication; and emergence of suicidality related co-morbidities after treatment.
This proposal will focus on developing a web-based comprehensive methodology for the assessment and monitoring of suicidality and its mediators in children and adolescents using the HealthTrackerTM (a paediatric web-based health outcome monitoring system), with the aim of developing a Suicidality Assessment and Monitoring Module, a Bio-psycho-social Mediators of Suicidality Assessment Module, and a Suicidality-Related Psychiatric and Physical Illness Module. The information obtained will be used to computer-generate classification of suicidality using the Classification of Suicide-Related Thoughts and Behaviour (Silverman et al, 2007) and the Columbia Classification Algorithm of Suicidal Assessment (C-CASA) (Posner et al, 2007). The existing Medication Characteristics Module will be expanded to allow documentation of pharmacological characteristics of medication, to explore whether they mediate MRS. The methodology will then be tested in 3 paediatric observational trials (risperidone in conduct disorder; fluoxetine in depression, and montelukast in bronchial asthma) and standardized, which can be used pharmacovigilance and in epidemiological, observational, and registration trials.

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

KING'S COLLEGE LONDON
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 119 023,19
Administrative Contact
Paul Labbett (Mr.)

Participants (18)

STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 37 058,02
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maarten Van Langen (Mr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 27 972,82
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
J.J. Breeuwsma (Mr.)
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 71 775,90
Address
Square J 5
68159 Mannheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ralf Dittmann (Prof.)
UNIVERSITAET ULM
Germany
EU contribution
€ 100 294,16
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 60 231,22
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Peek (Mr.)
THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON

Participation ended

United Kingdom
EU contribution
€ 85 000
Address
Brunswick Square 29-39
WC1N 1AX London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Macey Murrey (Dr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 109 900,05
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Christophe Misse (Mr.)
CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain
EU contribution
€ 85 896,49
Address
Calle Monforte De Lemos 5
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Manuel Sanchez Delgado (Mr.)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 184 891,12
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
Administrative Contact
Sara Jane Hurst (Ms.)
UNIVERSITA DEGLI STUDI DI CAGLIARI
Italy
EU contribution
€ 165 745,53
Address
Via Universita 40
09124 Cagliari
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giuseppina Tore (Ms.)
True Clarity Limited

Participation ended

United Kingdom
EU contribution
€ 143 610
Address
Londonderry Farm, Keynsham Road, The Hay Barn
BS30 6EL Willsbridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrew Davies (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 113 941
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 41 006
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Annick Bertault (Ms.)
Concentris Research Management GmbH
Germany
EU contribution
€ 300 467,54
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ameli Schwalber (Ms.)
GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST

Participation ended

United Kingdom
Address
Great Ormond Street
WC1N 3JH London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Claire Newton (Ms.)
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Canada
Address
1-560 Enterprise Square 10230 Jasper Avenue Research Services Office
T5J 4P6 Edmonton Alberta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Julaine Herst (Ms.)
HEALTHTRACKER LTD
United Kingdom
EU contribution
€ 305 420
Address
Foxon Close 18
CR3 5SY Caterham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nikola Penkov (Mr.)
CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
France
EU contribution
€ 47 766,96
Address
Avenue Du Doyen Gaston Giraud 191
34000 Montpellier
Activity type
Other
Administrative Contact
Valerie Handweiler (Mrs.)