Skip to main content

Epigenetics towards systems biology

Objective

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is needed to understand their dynamic functional relationships. This NoE identified 4 areas aiming at: 1) characterizing the molecular dynamics of epigenetic systems at the single molecule and cell level, 2) linking genotypes to epigenotypes, 3) investigating how environmental, developmental and metabolic signals act upon the epigenome, and 4) understanding epigenetic inheritance through replication, mitosis and meiosis. The common objective is to address fundamental epigenetic mechanisms in quantitative terms both spatially and temporally. The ultimate goal is to express the underlying dynamic events in mathematical terms in order to model and predict how the balance between maintenance and erasure of epigenetic information varies in specific developmental contexts under normal or pathological conditions. A major effort on data management and technology will provide standardised protocols for processing, normalising, and analysing each type of epigenetics data set. Common platforms, tools and resources including a key multilayer toolbox will be implemented for wide use and easy access for researchers, within the NoE and the epigenetics community at large. This NoE will function as an essential bridge between epigenetics researchers and the systems biology community. In the NoE, 22 teams will join efforts to address Epigenetics questions from a systems biology perspective. The combination of a strong training plan together with extension through open targeted calls to recruit young talent will further contribute to build a coherent new EpiGeneSys Area of European Research.

Call for proposal

FP7-HEALTH-2010-two-stage
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Other
EU contribution
€ 3 891 210,72
Administrative Contact
Julie Zittel (Mrs.)

Participants (27)

INSTITUT CURIE
France
EU contribution
€ 488 400
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Administrative Contact
Corinne Cumin (Ms.)
THE BABRAHAM INSTITUTE
United Kingdom
EU contribution
€ 724 000
Address
Babraham Hall
CB22 3AT Cambridge
Activity type
Research Organisations
Administrative Contact
Caroline Edmonds (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 253 878
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 264 000
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Polik (Ms.)
CANCER RESEARCH UK LBG
United Kingdom
EU contribution
€ 260 660
Address
St John Street 407 Angel Building
EC1V 4AD London
Activity type
Research Organisations
Administrative Contact
Louisa Jacobs (Ms.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 701 270,40
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 383 999
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helen New (Ms.)
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 318 999,20
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Zoe Kidd (Ms.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 564 000
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
Administrative Contact
Daniela Moll
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 742 799
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Axel Imhof (Prof.)
Novartis Forschungsstiftung

Participation ended

Switzerland
EU contribution
€ 362 945,76
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
Administrative Contact
Dorothy Searles (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 263 600
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Conrad Wenger (Mr.)
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria
EU contribution
€ 325 228,89
Address
Dr Bohrgasse 3
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tanja Winkler (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 321 230,80
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Tom Ratcliff (Mr.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 598 217,09
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 149 978
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 150 000
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
Administrative Contact
Steve Brooks (Dr.)
STICHTING WAGENINGEN RESEARCH

Participation ended

Netherlands
EU contribution
€ 40 832,34
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
Administrative Contact
Gerard Pitlo (Mr.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 149 996,40
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
David Davison (Mr.)
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
Germany
EU contribution
€ 150 000
Address
Ackermannweg 4
55128 Mainz
Activity type
Research Organisations
Administrative Contact
Franziska Hornig (Mrs.)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 260 000
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Mariana Morlans (Ms.)
UMEA UNIVERSITET
Sweden
EU contribution
€ 150 000
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingela Sandström (Mrs.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 210 600
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Laurie Louis-Joseph (Ms.)
UNIVERSITAET POTSDAM
Germany
EU contribution
€ 119 178,40
Address
Am Neuen Palais 10
14469 Potsdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Regina Gerber (Dr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 150 000
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Geurt Van Renselaar (Mr.)
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
Administrative Contact
Dorothy Searles (Ms.)
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
Address
1 Midland Road
NW1 1AT London
Activity type
Research Organisations
Administrative Contact
Heather Joanne Woods (Ms.)