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A Systems Biology Approach to controlling Nematode Infections of Livestock

Objective

Nematodes are among the most serious threats to livestock. They cause disease and death but they also compromise production. Even a mild infection can cause a relative protein deficiency and reduce weight gain by 25% . In the UK sheep industry alone, nematode infection costs over 100 million Euros a year .
The mainstay of current control measures is anthelmintic treatment but this is threatened by the evolution of drug resistance in parasite populations. Alternative or supplementary control measures are urgently needed. The most promising option for control of nematodes is exploitation of genetic variation which is cheap, surprisingly rapid and has proved to be successful in Australia and New Zealand. There are two obstacles to exploiting genetic variation in resistance to nematodes. Many farmers lack expertise in breeding for disease resistance; simplified breeding strategies that utilise markers for disease resistance will help here. Also, there are concerns about sustainability of breeding for resistance to nematodes.

A systems biology approach is necessary in order to develop the comprehensive understanding necessary to simplify breeding to ensure that disease control is likely to be sustainable. A systems approach will also help to identify the most suitable combination of approaches under different circumstances. Systems biology combines a variety of disciplines in a quantitative way to achieve a coherent, consistent and comprehensive understanding of host-parasite relationships.

This project aims to identify markers for host resistance to nematodes and to enhance our understanding of the host-parasite interaction. We will train a cadre of researchers with the necessary skills to apply quantitative approaches to parasitology and with the essential experience to apply this knowledge to the livestock sector.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /medical and health sciences/health sciences/parasitology

Call for proposal

FP7-PEOPLE-2010-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

UNIVERSITY OF GLASGOW
Address
University Avenue
G12 8QQ Glasgow
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 736 605
Administrative Contact
Michael James Stear (Prof.)

Participants (8)

UNIVERSIDAD DE LEON
Spain
EU contribution
€ 448 492
Address
Avenida Facultad 25
24004 Leon
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carmen Martinez-Rey (Ms.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 502 566
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Jacques Cabaret (Dr.)
AGRIS SARDEGNA - AGENZIA PER LA RICERCA IN AGRICOLTURA

Participation ended

Italy
Address
Localita Bonassai Ss 291 Km 18 6
07100 Sassari
Activity type
Research Organisations
Administrative Contact
Antonello Carta (Dr.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 496 512
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Torres Sweeney (Prof.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 473 988
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerda Bakker (Ms.)
BAYERISCHE LANDESANSTALT FUR LANDWIRTSCHAFT
Germany
EU contribution
€ 444 030
Address
Vottinger Strasse 38
85354 Freising
Activity type
Research Organisations
Administrative Contact
Johannes Buitkamp (Dr.)
ReactivLab Ltd
United Kingdom
EU contribution
€ 57 330
Address
The Square, University Avenue 13
G12 8QQ Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter David Eckersall (Prof.)
TOPIGS NORSVIN RESEARCH CENTER BV
Netherlands
EU contribution
€ 206 012
Address
Schoenaker 6
6641 SZ Beuningen Gld
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Merks (Dr.)