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Systems microscopy – a key enabling methodology for next-generation systems biology

Objective

Biological processes occur in space and time, but current experimental methods for systems biology are limited in their ability to resolve this spatiotemporal complexity of life. In addition, traditional “omics” methods often suffer from limited sensitivity and need to average over populations of cells at the expense of cell to cell variation. Next-generation systems biology therefore requires methods that can capture data and build models in four dimensions, three-dimensional space and time, and needs to address dynamic events in single living cells. In fact, recent advances in automated fluorescence microscopy, cell microarray platforms, highly specific probes, quantitative image analysis and data mining provide a powerful emerging technology platform to enable systems biology of the living cell. These imaging technologies, here referred to as “Systems microscopy”, will be a cornerstone for next-generation systems biology to elucidate and understand complex and dynamic molecular, sub-cellular and cellular networks. As a paradigm to enable systems biology at the cellular scale of biological organization, this NoE will have as its core biological theme two basic but complex cellular processes that are highly relevant to human cancer: cell division and cell migration. Methods, strategies and tools established here will be applicable to many disease-associated processes and will be instrumental for obtaining a systems level understanding of the molecular mechanisms underlying human diseases as manifested at the living cell level.
Through close multidisciplinary collaborations in our programme of joint activities this NoE will develop a powerful enabling platform for next-generation systems biology and will apply these tools to understand cellular systems underlying human cancer. This provides a unique opportunity for Europe to acquire a global lead in systems microscopy.

Field of science

  • /social sciences/sociology/social problems/migration
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/computer and information sciences/data science/data mining

Call for proposal

FP7-HEALTH-2010-two-stage
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 061 962,98
Administrative Contact
Cecilia Tilly (Ms.)

Participants (10)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 3 398 234,81
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Phil Irving (Dr.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 1 640 693,41
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 775 421,01
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Participation ended

Switzerland
EU contribution
€ 79 053,66
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel W. Gerlich (Prof.)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 780 800,23
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ton Brouwer (Mr.)
UNIVERSIDAD DE MALAGA
Spain
EU contribution
€ 671 407,08
Address
Avda Cervantes, Num. 2
29016 Malaga
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jose Antonio Molina Ruiz (Mr.)
Idea Bio-Medical Ltd.
Israel
EU contribution
€ 340 443,22
Address
Prof. Bergman St. 2
76705 Rehovot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Yuval Keren (Mr.)
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria
EU contribution
€ 838 673,60
Address
Dr Bohrgasse 3
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tanja Winkler (Ms.)
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Spain
EU contribution
€ 200 000
Address
Avinguda Carl Friedrich Gauss 3
08860 Castelldefels
Activity type
Research Organisations
Administrative Contact
Dolors Mateu (Mrs.)
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
France
EU contribution
€ 200 000
Address
Boulevard Saint Michel 60
75272 Paris
Activity type
Research Organisations
Administrative Contact
Florence Thepenier (Ms.)