CORDIS
EU research results

CORDIS

English EN
Systems microscopy – a key enabling methodology for next-generation systems biology

Systems microscopy – a key enabling methodology for next-generation systems biology

Objective

Biological processes occur in space and time, but current experimental methods for systems biology are limited in their ability to resolve this spatiotemporal complexity of life. In addition, traditional “omics” methods often suffer from limited sensitivity and need to average over populations of cells at the expense of cell to cell variation. Next-generation systems biology therefore requires methods that can capture data and build models in four dimensions, three-dimensional space and time, and needs to address dynamic events in single living cells. In fact, recent advances in automated fluorescence microscopy, cell microarray platforms, highly specific probes, quantitative image analysis and data mining provide a powerful emerging technology platform to enable systems biology of the living cell. These imaging technologies, here referred to as “Systems microscopy”, will be a cornerstone for next-generation systems biology to elucidate and understand complex and dynamic molecular, sub-cellular and cellular networks. As a paradigm to enable systems biology at the cellular scale of biological organization, this NoE will have as its core biological theme two basic but complex cellular processes that are highly relevant to human cancer: cell division and cell migration. Methods, strategies and tools established here will be applicable to many disease-associated processes and will be instrumental for obtaining a systems level understanding of the molecular mechanisms underlying human diseases as manifested at the living cell level.
Through close multidisciplinary collaborations in our programme of joint activities this NoE will develop a powerful enabling platform for next-generation systems biology and will apply these tools to understand cellular systems underlying human cancer. This provides a unique opportunity for Europe to acquire a global lead in systems microscopy.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

KAROLINSKA INSTITUTET

Address

Nobels Vag 5
17177 Stockholm

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 061 962,98

Administrative Contact

Cecilia Tilly (Ms.)

Participants (10)

Sort alphabetically

Sort by EU Contribution

Expand all

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 3 398 234,81

WEIZMANN INSTITUTE OF SCIENCE LTD

Israel

EU Contribution

€ 1 640 693,41

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 775 421,01

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 79 053,66

UNIVERSITEIT LEIDEN

Netherlands

EU Contribution

€ 780 800,23

UNIVERSIDAD DE MALAGA

Spain

EU Contribution

€ 671 407,08

Idea Bio-Medical Ltd.

Israel

EU Contribution

€ 340 443,22

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH

Austria

EU Contribution

€ 838 673,60

FUNDACIO INSTITUT DE CIENCIES FOTONIQUES

Spain

EU Contribution

€ 200 000

ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS

France

EU Contribution

€ 200 000

Project information

Grant agreement ID: 258068

Status

Closed project

  • Start date

    1 January 2011

  • End date

    31 December 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 15 964 673,33

  • EU contribution

    € 11 986 690

Coordinated by:

KAROLINSKA INSTITUTET

Sweden