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Systems Biology of Colorectal Cancer

Objective

Colorectal cancer (CRC) is one of the most common cancers in both males and females, and it is perhaps the best understood of all epithelial tumors in terms of its molecular origin. Yet, despite large amount of work that has concentrated on understanding of colon tumorigenesis, we still do not know the full complement of molecular lesions that are individually necessary – and together sufficient – to cause colorectal cancer. Neither do we understand why some specific mutations that are relatively rare in other tumors (e.g. loss of the APC tumor suppressor) are extremely common in colorectal cancer. We propose here to use the tools of systems biology to develop a quantitative and comprehensive model of colorectal tumorigenesis. The model will include a “wiring diagram” that identifies cell-type specific and oncogenic pathways that contribute to colon tumorigenesis, and explains in molecular detail how a genotype of an individual CRC leads to activation of downstream genes that drive uncontrolled cell growth. This model will subsequently be used to find novel therapeutic targets, to guide genetic screening to identify individuals with elevated risk for developing CRC, and to classify patients into molecular subgroups to select the treatment combination which is optimal for each patient (personalized medicine). The specific objectives of the SYSCOL project are:
1. Identify genetic markers for individual risk using genotyping and sequencing of germline DNA from sporadic and familial CRC cases and controls
2. Identify genes and regulatory elements that contribute to colorectal cancer cell growth
3. Use data from Aims 1-2 to develop a quantitative model for colorectal tumorigenesis
4. Apply the model for identification of high-risk individuals, for molecular classification of the disease, and for identification of novel molecular treatment targets

Call for proposal

FP7-HEALTH-2010-two-stage
See other projects for this call

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 398 332,20
Administrative Contact
Patricia Degnell (Ms.)

Participants (10)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 820 151,10
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lynn Burrows (Ms.)
AARHUS UNIVERSITETSHOSPITAL, SKEJBY
Denmark
EU contribution
€ 921 238,35
Address
Brendstrupgaardsvej 100
8200 Aarhus N
Activity type
Research Organisations
Administrative Contact
Christina Bak Pedersen (Ms.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 916 137,20
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emmanouil Dermitzakis (Prof.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 924 005,90
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 1 795 994,10
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Ms.)
JOHNS HOPKINS UNIVERSITY
United States
EU contribution
€ 1 251 353,95
Address
North Charles Street 3400
21218 Baltimore
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kate Mollen (Ms.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
EU contribution
€ 690 761,15
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Activity type
Research Organisations
Administrative Contact
Carole Amroune (Ms.)
STICHTING RADBOUD UNIVERSITEIT
Netherlands
EU contribution
€ 932 274,10
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Geurt Van Renselaar (Mr.)
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
EU contribution
€ 853 027,90
Address
Old Brompton Road 123
SW7 3RP London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lydia Turner (Ms.)
GENEXPLAIN GMBH
Germany
EU contribution
€ 496 720,05
Address
Am Exer 19 B
38302 Wolfenbuttel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Kel (Dr.)