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Glycomics by High-throughput Integrated Technologies

Objective

Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innovative, rapid, and high-throughput (HTP) technologies that will translate the discovery of cancer-associated glycobiomarkers from basic science to clinical application.
The GlycoHIT consortium brings a highly experienced, innovative and interdisciplinary team of researchers from Europe, China and USA representing academia, industry and clinical fields to significantly enhance some of the existing glycoanalytical technologies and to advance novel HTP glycoanalytical technologies beyond current state of the art.

▪ Microchip technology and novel partitioning methods will be exploited for nanoscale HTP separations of serum glycoproteins for analysis by HPLC or LC–MS.
▪ In parallel, lectin array technology will be radically improved by the innovative use of recombinant human lectins and lectin mimics derived by screening large phage displayed combinatorial libraries.
▪ Aptamer libraries will be exploited for identification of lectin mimics and development of a glycosignature platform
▪ Compatibility of the lectin/lectin mimic array technologies with novel label-free biosensors will be explored.

Newly-developed technologies will be validated by analysis of serum samples from a variety of cancer patient cohorts and will be supported throughout by experimental interaction analysis, complex structural modelling and informatics.

Effective project management, commercially-aware intellectual property management and targeted dissemination activities supplement the core science and ensure maximum impact for the project.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /engineering and technology/environmental biotechnology/biosensing

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 830 455
Administrative Contact
Lokesh Joshi (Prof.)

Participants (14)

AGILENT TECHNOLOGIES ISRAEL LTD
Israel
EU contribution
€ 241 120
Address
Em Hamoshavot Road 94
49527 Petach Tikva
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Zohat Yakhini (Dr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 336 640
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hans-Joachim Gabius (Prof.)
NATIONAL INSTITUTE FOR BIOPROCESSING RESEARCH AND TRAINING LIMITED
Ireland
EU contribution
€ 274 654
Address
Fosters Avenue Mount Merrion
4 Blackrock Dublin
Activity type
Research Organisations
Administrative Contact
Pauline Rudd (Prof.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 213 036
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Janne Lethio (Dr.)
INSTITUT PASTEUR
France
EU contribution
€ 186 230,40
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Benno Schwikowski (Dr.)
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 90 600
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne-Lise Børresen-Dale (Prof.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 158 000
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz (Mr.)
UNIVERSITE DE MONS
Belgium
EU contribution
€ 84 400
Address
Place Du Parc 20
7000 Mons
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sven Saussez (Prof.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 227 513
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jimenez Arroyo (Mr.)
TSINGHUA UNIVERSITY
China
EU contribution
€ 82 800
Address
Qing Hua Yuan
100084 Beijing
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jun Ma (Dr.)
HUNAN UNIVERSITY
China
EU contribution
€ 82 800
Address
Lushan South Road 1
410082 Changsha
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jian-Hui Jiang (Prof.)
BRISTOL-MYERS SQUIBB COMPANY CORP
United States
EU contribution
€ 57 572
Address
Park Avenue 345
10154 New York
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kirk Leister (Dr.)
PINTAIL LTD
Ireland
EU contribution
€ 127 236
Address
Springhill Avenue 77
A94 K542 Blackrock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ciaran Clissmann (Mr.)
KOKURITSU DAIGAKU HOJIN HOKKAIDO DAIGAKU
Japan
Address
Kita 8 Nishi 5 Kita Ku
060 0808 Sapporo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Shin-Ichiro Nishimura (Prof.)