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Integrated In Silico Models for the Prediction of Human Repeated Dose Toxicity of Cosmetics to Optimise Safety

Objective

The COSMOS project will address the assessment needs of the cosmetics industry by delivering an integrated suite of computational tools to predict the effects of long-term exposure to cosmetic ingredients in humans, thus reducing the need for repeated dose toxicity testing in animals. To achieve this, individual modules comprising: (new) databases, thresholds of toxicological concern (TTC), in silico toxicology (grouping, read-across and QSAR), in vitro data and physiologically-based pharmacokinetic (PBPK) modelling, will be used to construct flexible workflows for assessing toxicity. The COSMOS project will be informed by the needs of industry through active stakeholder engagement, and will utilise innovative technologies from outside the cosmetics area. New databases for TTC and modelling studies will be created by harvesting US FDA legacy data for cosmetics. New and current databases will be combined to advance the state-of-the-art providing a transparent, freely-available public resource. Grouping and read-across will be achieved mechanistically and on the basis of structural similarity. The effective dose-response at the target organ will be estimated from in vitro effects and PBPK models, establishing an alternative (non-animal) basis for risk assessment. All models and Workflows developed will be transparent, fully documented and open access. The partners include world leaders committed to donating software and algorithms to support the open architecture. Data and models will be integratable with existing systems. Workflows will be automated through the KNIME software.

Field of science

  • /natural sciences/computer and information sciences/software
  • /natural sciences/computer and information sciences/databases

Call for proposal

FP7-HEALTH-2010-Alternative-Testing
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

LIVERPOOL JOHN MOORES UNIVERSITY
Address
Rodney Street 2 Egerton Court
L3 5UX Liverpool
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 577 496
Administrative Contact
Mark Cronin (Prof.)

Participants (14)

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Belgium
EU contribution
€ 355 026
Address
Rue De La Loi 200
1049 Brussels
Activity type
Research Organisations
Administrative Contact
Andrew Paul Worth (Dr.)
U.S. Food & Drug Administration
United States
Address
New Hampshire Avenue 10903
20993 Silver Spring
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Mitchell Cheeseman (Dr.)
HENKEL KGaA
Germany
Address
Henkelstrasse 67
40191 Dusseldorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Detlef Keller (Dr.)
Merck KGaA
Germany
EU contribution
€ 15 000
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Soheila Anzali (Dr.)
INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
France
EU contribution
€ 365 000
Address
Parc Technologique Alata
60550 Verneuil En Halatte
Activity type
Research Organisations
Administrative Contact
Alexandre Pery (Dr.)
INTERNATIONAL LIFE SCIENCES INSTITUTE EUROPEAN BRANCH AISBL
Belgium
EU contribution
€ 117 500
Address
Av. E. Mounier 83
1200 Bruxelles
Activity type
Research Organisations
Administrative Contact
Nico Van Belzen (Dr.)
ALTAMIRA LLC
United States
EU contribution
€ 237 500
Address
Candlewood Drive 1455
43235 1623 Columbus Oh
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Chihae Yang (Dr.)
INSILICO BIOTECHNOLOGY AG
Germany
EU contribution
€ 195 000
Address
Meitnerstrasse 9
70563 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Klaus Mauch (Mr.)
KNIME.COM AG
Switzerland
EU contribution
€ 250 000
Address
Technoparkstrasse 1
8005 Zurich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Berthold (Prof.)
MOLECULAR NETWORKS GMBH COMPUTERCHEMIE
Germany
EU contribution
€ 435 200
Address
Neumeyerstr 28-34
90411 Nurnberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lothar Terfloth (Dr.)
INSTITUT PO BIOFIZIKA I BIOMEDITSINSKO INZHENERSTVO (INSTITUTE OF BIOPHYSICS AND BIOMEDICAL ENGINEERING)
Bulgaria
EU contribution
€ 240 000
Address
Akad. G. Bonchev Bl. 21
1113 Sofia
Activity type
Research Organisations
Administrative Contact
Ivanka Tsakovska (Dr.)
KEMIJSKI INSTITUT
Slovenia
EU contribution
€ 45 000
Address
Hajdrihova 19
1000 Ljubljana
Activity type
Research Organisations
Administrative Contact
Marjan Vracko (Dr.)
UNIVERSITY OF BRADFORD
United Kingdom
EU contribution
€ 282 500
Address
Richmond Road
BD7 1DP Bradford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Neagu (Dr.)
S-IN SOLUZIONI INFORMATICHE SRL
Italy
EU contribution
€ 229 444
Address
Via G Ferrari 14
36100 Vicenza
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Manuela Pavan (Dr.)