Obiettivo With the exception of infrequent random mutations (and immune cell receptors), it is widely believed that the genomic content should be fixed in an organism throughout its body and its lifespan. It is therefore clear why the discovery of proteins that can edit the RNA have generated much interest. However, only very few targets have been discover so far. I have recently made important progress in this area by developing novel methods to model and detect RNA editing in mammals. Using a combination of computational approaches and next generation sequencing based technology, I am able, for the first time, to perform large-scale comprehensive screen and sketch the “editosome” fingerprints. As an independent investigator, I will use the padlock probes technology followed by next generation sequencing to associate different diseases with altered editing levels and investigate the impact of RNA editing on genome evolution and development. To achieve these aims, my lab will use a combination of molecular biology and computational approaches. . It is my expectation that these studies will provide fundamental new insights into the mechanism of RNA editing and their role in human biology, within a timeframe of several years. Campo scientifico medical and health sciencesbasic medicineimmunologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological scienceszoologymammalogynatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesmolecular biology Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Invito a presentare proposte FP7-PEOPLE-2009-RG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IRG - International Re-integration Grants (IRG) Coordinatore BAR ILAN UNIVERSITY Contributo UE € 100 000,00 Indirizzo BAR ILAN UNIVERSITY CAMPUS 52900 Ramat Gan Israele Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Estelle Waise (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
