Obiettivo Genome Instability has been recognized as causal factor of cancer and recently also as a major contributing factor of aging. A number of progeroid (premature aging-like) syndromes are linked to defects in nucleotide excision repair (NER). NER thus provides a highly relevant experimental system to study the role of genome stability in aging. Using the NER system we recently uncovered a novel link between DNA damage accumulation and the regulation of longevity assurance programs. We propose to use the powerful genetic system of C. elegans to identify mechanisms through which the stochastic accumulation of damage impacts aging and genetic pathways of longevity regulation. We will pursue three complementary experimental strategies: (1) genetic identification of novel response pathways to persistent DNA damage, (2) investigation of DNA damage resistance mechanisms that promote longevity, and (3) a targeted candidate approach to uncover the underlying mechanisms that ensure genome integrity in lifespan extension. This proposal aims at the discovery of novel genes functioning in genome stability and longevity regulation that might be instrumental for the development of preventive therapeutic strategies for age-related pathologies as well as for the treatment of rare genetic progeroid disorders. Campo scientifico natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesbiological sciencesgeneticsgenomes Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-SG-LS3 - ERC Starting Grant - Cellular and Developmental Biology Invito a presentare proposte ERC-2010-StG_20091118 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SG - ERC Starting Grant Istituzione ospitante KLINIKUM DER UNIVERSITAET ZU KOELN Contributo UE € 1 000 626,00 Indirizzo Kerpener Strasse 62 50937 Koeln Germania Mostra sulla mappa Regione Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Bjoern Schumacher (Prof.) Contatto amministrativo Petra Schreiner-Kaub (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto KLINIKUM DER UNIVERSITAET ZU KOELN Germania Contributo UE € 1 000 626,00 Indirizzo Kerpener Strasse 62 50937 Koeln Mostra sulla mappa Regione Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Bjoern Schumacher (Prof.) Contatto amministrativo Petra Schreiner-Kaub (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAT ZU KOLN Partecipazione conclusa Germania Contributo UE € 447 774,00 Indirizzo ALBERTUS MAGNUS PLATZ 50931 Koln Mostra sulla mappa Regione Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Christian Klar (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
