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Rationally Designed Aquatic Receptors integrated in label-free biosensor platforms for remote surveillance of toxins and pollutants

Rationally Designed Aquatic Receptors integrated in label-free biosensor platforms for remote surveillance of toxins and pollutants

Objective

RADAR is a 7-member consortium that aims to develop a robust, sensitive, and versatile label-free, biosensor platform for spot measurements and on-line monitoring of toxins and pollutants in food production processes and in the aquatic environment.
Specificity towards chemical pollutants and toxins is achieved by using recombinant receptors (namely the estrogen receptor and the aryl hydrocarbon receptor) whose amino acid sequences have been rationally designed based on genomic and functional information from aquatic organisms.
Sensitivity of the biosensor is increased by the unique combination of isotachophoretic pre-concentration step, and surface nanostructuring & chemical modification.
The integration of the label-free detection sensors with an on-line automated sample handling and a wireless communication system will yield a best-in-class biosensor platform for robust, specific and sensitive detection of EDCs and PAHs in difficult operating conditions.
To validate the RADAR biosensor the consortium will test the biosensors in fresh and marine water, in fish farms, and in food products such as fish, fruit juices, and milk. Through their contacts in these industries, the partners will evaluate the performance of the biosensors in such environments, analyzing a representative number of samples and reporting on the stability, ruggedness and accuracy of the sensors used under laboratory and real test conditions.

This project is expected to have a high economic impact, since our cost-effective sensor could find a worldwide distribution in most food production and water testing lines as supported by Agilent Technologies Inc.

Coordinator

CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT

Address

Rue Jaquet Droz 1
2000 Neuchatel

Switzerland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 952 267

Administrative Contact

Peter Seitz (Prof.)

Participants (6)

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JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

Belgium

EU Contribution

€ 802 650

OPTICS BALZERS AG

Liechtenstein

EU Contribution

€ 277 210

FONDAZIONE PER L'ISTITUTO DI RICERC A IN BIOMEDICINA

Switzerland

EU Contribution

€ 284 387

STICHTING WAGENINGEN RESEARCH

Netherlands

EU Contribution

€ 313 662

Elysium Projects Limited

United Kingdom

EU Contribution

€ 215 250

NACIONALNI INSTITUT ZA BIOLOGIJO

Slovenia

EU Contribution

€ 80 701

Project information

Grant agreement ID: 265721

Status

Closed project

  • Start date

    1 January 2011

  • End date

    31 December 2014

Funded under:

FP7-KBBE

  • Overall budget:

    € 3 896 412

  • EU contribution

    € 2 926 127

Coordinated by:

CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT

Switzerland

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