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Developing the Next Generation of Biocatalysts for Industrial Chemical Synthesis

Developing the Next Generation of Biocatalysts for Industrial Chemical Synthesis

Objective

BIONEXGEN will develop the next generation of biocatalysts to be used for eco-efficient manufacturing processes in the chemical industry. A collaboration by industrial and academic partners have identified the key technology fields of amine synthesis, polymers from renewable resources, glycoscience and wider oxidase application as four key areas where the next generation of biocatalysts that will lead to improvements in both economic and environmental performance of the chemical manufacturing industries. This project will enable industry to use renewable resources with reduced greenhouse gas production as compared to their fossil counterparts and deliver biotechnological routes with reduced energy consumption and less toxic wastes compared to conventional chemical processes.
Routes to specialised, high-value chemicals (e.g. chiral chemical compounds) normally require long chemical synthetic routes involving complex reaction steps with toxic side products and waste streams and this project will allow these methods to be replaced by clean biocatalysis routes. To broaden the range of fine and speciality chemicals and intermediates produced by biotechnological routes, research will address: (i) design and optimisation of enzymes to be used in synthetic chemistry, (ii) the selection/development of modified microorganisms which are resistant to heat, pressure or low pH when used in the production of chemical entities and allow (iii) the integration of biotechnological steps into conventional chemical processes.
The project will develop and integrate with chemical steps the biotechnological manufacturing routes for the synthesis of fine and speciality chemicals especially amines, oligosaccharides and renewable polymer intermediates which are better in terms of eco-efficiency, economic potential, complexity and /or specificity of the synthetic pathways than those currently employed.
Dissemination strategy will enhance the impact of this work through three separate initiatives. Economic viability and eco-efficiency will be evaluated and assessed on a quantitative basis and these results will be published in the scientific literature.
Green chemistry initiatives in the BIONEXGEN project and the FP7 contributions will be presented to the wider public on a project website and through material displays at the museum in Manchester and the Big Saturday event in Manchester Science Week. An overall end of project meeting in Brussels will invite a range of political decision makers and industry leaders to attend and will ensure maximum impact.
The project was devised with a strong involvement of industrial partners, in particular SMEs and is strength of this project and will contribute significantly to ensure application of the technology.
This combination of technical will lead to the development of new green chemical manufacturing technology platforms that will be tested for specific targets in the European chemical manufacturing industries and use these as case studies for dissemination on a broad front.
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Coordinator

THE UNIVERSITY OF MANCHESTER

Address

Oxford Road
M13 9pl Manchester

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 180 946

Administrative Contact

Liz Fay (Ms.)

Participants (16)

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UNIVERSITAET STUTTGART

Germany

EU Contribution

€ 524 760

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 699 000

MIKROBIOLOGICKY USTAV - AVCR, V.V.I.

Czechia

EU Contribution

€ 126 000

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

EU Contribution

€ 641 600

CLEA TECHNOLOGIES BV

Netherlands

EU Contribution

€ 495 734

ENTRECHEM SL

Spain

EU Contribution

€ 288 000

UNIVERSIDAD DE OVIEDO

Spain

EU Contribution

€ 306 000

GALAB LABORATORIES GMBH

Germany

EU Contribution

€ 288 000

LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE

Germany

EU Contribution

€ 723 600

ACIB GmbH

Austria

EU Contribution

€ 624 539

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

EU Contribution

€ 349 800

LentiKat's a.s.

Czechia

EU Contribution

€ 202 500

SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE

Slovakia

EU Contribution

€ 307 200

BASF SE

Germany

EU Contribution

€ 567 622

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 381 767

CHEMISTRY INNOVATION LIMITED

United Kingdom

EU Contribution

€ 67 815

Project information

Grant agreement ID: 266025

Status

Closed project

  • Start date

    1 February 2011

  • End date

    31 January 2014

Funded under:

FP7-KBBE

  • Overall budget:

    € 10 639 428

  • EU contribution

    € 7 774 883

Coordinated by:

THE UNIVERSITY OF MANCHESTER

United Kingdom