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Developing the Next Generation of Biocatalysts for Industrial Chemical Synthesis

Objective

BIONEXGEN will develop the next generation of biocatalysts to be used for eco-efficient manufacturing processes in the chemical industry. A collaboration by industrial and academic partners have identified the key technology fields of amine synthesis, polymers from renewable resources, glycoscience and wider oxidase application as four key areas where the next generation of biocatalysts that will lead to improvements in both economic and environmental performance of the chemical manufacturing industries. This project will enable industry to use renewable resources with reduced greenhouse gas production as compared to their fossil counterparts and deliver biotechnological routes with reduced energy consumption and less toxic wastes compared to conventional chemical processes.
Routes to specialised, high-value chemicals (e.g. chiral chemical compounds) normally require long chemical synthetic routes involving complex reaction steps with toxic side products and waste streams and this project will allow these methods to be replaced by clean biocatalysis routes. To broaden the range of fine and speciality chemicals and intermediates produced by biotechnological routes, research will address: (i) design and optimisation of enzymes to be used in synthetic chemistry, (ii) the selection/development of modified microorganisms which are resistant to heat, pressure or low pH when used in the production of chemical entities and allow (iii) the integration of biotechnological steps into conventional chemical processes.
The project will develop and integrate with chemical steps the biotechnological manufacturing routes for the synthesis of fine and speciality chemicals especially amines, oligosaccharides and renewable polymer intermediates which are better in terms of eco-efficiency, economic potential, complexity and /or specificity of the synthetic pathways than those currently employed.
Dissemination strategy will enhance the impact of this work through three separate initiatives. Economic viability and eco-efficiency will be evaluated and assessed on a quantitative basis and these results will be published in the scientific literature.
Green chemistry initiatives in the BIONEXGEN project and the FP7 contributions will be presented to the wider public on a project website and through material displays at the museum in Manchester and the Big Saturday event in Manchester Science Week. An overall end of project meeting in Brussels will invite a range of political decision makers and industry leaders to attend and will ensure maximum impact.
The project was devised with a strong involvement of industrial partners, in particular SMEs and is strength of this project and will contribute significantly to ensure application of the technology.
This combination of technical will lead to the development of new green chemical manufacturing technology platforms that will be tested for specific targets in the European chemical manufacturing industries and use these as case studies for dissemination on a broad front.

Field of science

  • /natural sciences/chemical sciences/polymer science
  • /engineering and technology/environmental engineering/energy and fuels/fossil energy/natural gas
  • /natural sciences/chemical sciences/organic chemistry/amines
  • /engineering and technology/industrial biotechnology/bioprocessing technologies/biocatalysis

Call for proposal

FP7-KBBE-2010-4
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

THE UNIVERSITY OF MANCHESTER
Address
Oxford Road
M13 9PL Manchester
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 180 946
Administrative Contact
Liz Fay (Ms.)

Participants (16)

UNIVERSITAET STUTTGART
Germany
EU contribution
€ 524 760
Address
Keplerstrasse 7
70174 Stuttgart
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bernhard Hauer (Prof.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 699 000
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
John Woodley (Prof.)
MIKROBIOLOGICKY USTAV AV CR V.V.I
Czechia
EU contribution
€ 126 000
Address
Videnska 1083
142 00 Praha 4
Activity type
Research Organisations
Administrative Contact
Vladimir Kren (Prof.)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 641 600
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Poutsma (Dr.)
CLEA TECHNOLOGIES BV
Netherlands
EU contribution
€ 495 734
Address
Delftechpark 34
2628 XH Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ivo Van Der Laan (Mr.)
EntreChem SL
Spain
EU contribution
€ 288 000
Address
Edificio Cientifico Tecnologico Campus El Cristo
33006 Oviedo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Francisco Moris (Dr.)
UNIVERSIDAD DE OVIEDO
Spain
EU contribution
€ 306 000
Address
Calle San Francisco 3
33003 Oviedo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Hörlein (Dr.)
GALAB LABORATORIES GMBH
Germany
EU contribution
€ 288 000
Address
Am Schleusengraben 7
21029 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jürgen Kuballa (Dr.)
LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE
Germany
EU contribution
€ 723 600
Address
Weinberg 3
06120 Halle
Activity type
Research Organisations
Administrative Contact
Lothar Franzen (Mr.)
ACIB GMBH
Austria
EU contribution
€ 624 539
Address
Krenngasse 37/2
8010 Graz
Activity type
Research Organisations
Administrative Contact
Julia Studencki (Ms.)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 349 800
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pia Ahnlén (Ms.)
LentiKat's a.s.
Czechia
EU contribution
€ 202 500
Address
Pod Vinici 83
471 27 Straz Pod Ralskem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Radek Stloukal (Dr.)
SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE
Slovakia
EU contribution
€ 307 200
Address
Vazovova 5
81243 Bratislava
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Rebros (Dr.)
BASF SE
Germany
EU contribution
€ 567 622
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Roeper (Prof.)
University College London
United Kingdom
EU contribution
€ 381 767
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
CHEMISTRY INNOVATION LIMITED
United Kingdom
EU contribution
€ 67 815
Address
Burlington House Picadilly
W1J 0BA London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frank Harasiwka (Mr.)