Cel We aim to offer to science a molecular scale mechanism for communication and control. Using stereochemical information and conformational control as the mechanism by which that information is transmitted and processed, we take inspiration from the phenomenon of allostery in biology, and will put to dynamic use a set of conformationally controlled foldamer structures. We will use these structures to convey information over multi-nanometre distances, allowing control of chemical function from a remote site. By embedding the foldamers into membranes, we will control chemistry (eg catalytic activity) within an artificial vesicle by communicating information through the chemically impermeable phospholipid bilayer.To achieve our aim we will synthesise oligomeric and polymeric compounds with well-defined helical conformations, and use a stereochemical influence located at one terminus to induce a conformational preference (for the left or the right handed form of the helix) which is relayed to a site many nanometres distant. Precedent suggests that by employing polymeric structures we will achieve control even over micrometre scales. Simple but powerful new techniques will quantify the remote (on a molecular scale) transmission of information by NMR, circular dichroism spectrophotometry and/or fluorescence. The result of the information relay will be a detectable change in chemical reactivity or binding properties and one aim will be to vastly increase, by orders of magnitude, the distance over which remote stereochemical control is possible (from the current 2.5 nm to the order of >100 nm).The feature which distinguishes biology from chemistry is information, and in particular the ability to encode and process information using molecular interactions. Our project will take a step towards the development of designed chemical structures which can mimic, using far simpler molecules, the function of biological communication systems. Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-PE5 - ERC Advanced Grant - Materials and Synthesis Zaproszenie do składania wniosków ERC-2010-AdG_20100224 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca UNIVERSITY OF BRISTOL Wkład UE € 253 649,40 Adres BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Zjednoczone Królestwo Zobacz na mapie Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Jonathan Clayden (Prof.) Kontakt administracyjny Maria Davies (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITY OF BRISTOL Zjednoczone Królestwo Wkład UE € 253 649,40 Adres BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Zobacz na mapie Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Jonathan Clayden (Prof.) Kontakt administracyjny Maria Davies (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych THE UNIVERSITY OF MANCHESTER Zjednoczone Królestwo Wkład UE € 2 172 456,60 Adres OXFORD ROAD M13 9PL Manchester Zobacz na mapie Region North West (England) Greater Manchester Manchester Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Liz Fay (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
