Obiettivo Understanding the origin and evolution of eukaryotes, their genomes and organelles, are among the most important and exciting challenges facing biology. However, determining ancient gene origins tests methods and data to their limits, and it is unrealistic to expect progress to be easy. A comparative cross-disciplinary approach involving sophisticated phylogenetics allied with mathematical understanding, offers the best hope of obtaining robust hypotheses for gene and genomic origins. It is also necessary to look beyond the narrow focus of a few model organisms, and to thoughtfully embrace a wider selection of eukaryotic diversity. Over the past few years, my lab has studied the genomes and mitochondrial homologues (mitosomes and hydrogenosomes) of parasitic protozoa that represent significant health hazards in both the developed and developing world. These microbial eukaryotes will provide the model systems for investigations which aim to deliver major progress in understanding the importance of lateral gene transfer for eukaryotic genome origins and flux, for understanding how parasites exploit their host cells, and for identifying the essential functions of organelles related to mitochondria, which now appear to be vital components of all eukaryotic cells. Campo scientifico medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesmicrobiologyprotozoologynatural sciencesbiological sciencesgeneticsgenomeseukaryotic genomes Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-AG-LS8 - ERC Advanced Grant - Evolutionary, population and environmental biology Invito a presentare proposte ERC-2010-AdG_20100317 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-AG - ERC Advanced Grant Istituzione ospitante UNIVERSITY OF NEWCASTLE UPON TYNE Contributo UE € 1 998 703,00 Indirizzo KINGS GATE NE1 7RU Newcastle Upon Tyne Regno Unito Mostra sulla mappa Regione North East (England) Northumberland and Tyne and Wear Tyneside Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Thomas Martin Embley (Prof.) Contatto amministrativo Fiona Airey (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF NEWCASTLE UPON TYNE Regno Unito Contributo UE € 1 998 703,00 Indirizzo KINGS GATE NE1 7RU Newcastle Upon Tyne Mostra sulla mappa Regione North East (England) Northumberland and Tyne and Wear Tyneside Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Thomas Martin Embley (Prof.) Contatto amministrativo Fiona Airey (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato