CORDIS
EU research results

CORDIS

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Microbes in Allergy and Autoimmunity Related to the Skin

Project information

Grant agreement ID: 261366

Status

Closed project

  • Start date

    1 April 2011

  • End date

    31 March 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 827 362,24

  • EU contribution

    € 5 978 541,30

Coordinated by:

TYOTERVEYSLAITOS

Finland

Objective

Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know very little how microbe-host interaction triggers and regulate inflammatory cascade leading to allergic or autoimmune reaction. We propose that environmental and genetic factors, characteristic to particular disease, initiate a cascade of inflammatory events through the modulation of anti-microbial defence. The dysregulation of innate as well as adaptive immune responses leads to inappropriate responses to physical, microbial or allergen challenge, finally manifesting in the clinical symptoms of AD or PSO. We propose to use high-throughput whole microbiome and transcriptomics analysis with bioinformatics and systems biology to unravel the pathways during the host-pathogen interactions which may trigger an allergic or autoimmune reaction. We will identify key microbes and molecular targets to develop novel intervention strategies to decrease and prevent the burden of allergy and autoimmunity.

Coordinator

TYOTERVEYSLAITOS

Address

Topeliuksenkatu 41 B
00250 Helsinki

Finland

Activity type

Research Organisations

EU Contribution

€ 984 656,50

Administrative Contact

Harri Alenius (Prof.)

Participants (9)

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 1 595 979,20

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

EU Contribution

€ 367 779,60

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

EU Contribution

€ 654 380

INSTITUT CURIE

France

EU Contribution

€ 590 040

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Germany

EU Contribution

€ 319 156,80

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 856 468

ICOSAGEN AS

Estonia

EU Contribution

€ 324 118,80

Fios Genomics Limited

United Kingdom

EU Contribution

€ 127 500

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 158 462,40

Project information

Grant agreement ID: 261366

Status

Closed project

  • Start date

    1 April 2011

  • End date

    31 March 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 827 362,24

  • EU contribution

    € 5 978 541,30

Coordinated by:

TYOTERVEYSLAITOS

Finland