Cel Chronic hepatitis B virus (HBV) infection affects 350 million people worldwide and 25-30% of these individuals will die as a result of their infection mainly as a results of hepatocellular carcinoma HCC. Liver cirrhosis, high viral load and dietary exposure to aflatoxin are recognised as risk factors for hepatocellular carcinoma amongst HBV carriers. However, these variables do not account for all cases of HCC and decompensated cirrhosis is rarely ever seen in West Africa suggesting that advanced liver fibrosis may not be an important risk factor in this population. A large case control study on HCC will be used to evaluate the importance of liver fibrosis and other established risk factors in West Africa and to explore other potential oncogenic determinants. The case-control study will generate serum, urine and DNA samples for proteomic, metabonomic and genomic analysis to identify biomarkers and aetiological agents for HCC.Effective treatment for HBV infection is now available in the developed world but treatment programmes have not been developed for resource poor settings even though some of the effective medication is now available at low cost for HIV management. A trial of HBV treatment in a group of carefully selected high risk patients will be conducted to demonstrate that the incidence of HCC can be reduced in this population as has been observed in Asian patients. The treatment trial will also be used to evaluate the efficacy of screening by ultrasound for early tumours which can be treated with percutaneous alcohol injection.This comprehensive programme therefore aims to reveal novel aetiological factors for HCC, identify and evaluate biomarkers and demonstrate the efficacy of selective antiviral therapy to prevent HCC Dziedzina nauki medycyna i nauki o zdrowiumedycyna klinicznafarmakologia i farmacjalekmedycyna i nauki o zdrowiunauki o zdrowiuchoroby zakaźnewirus DNAwirusowe zapalenie wątroby typu Bmedycyna i nauki o zdrowiunauki o zdrowiuchoroby zakaźnewirus RNAHIVmedycyna i nauki o zdrowiumedycyna klinicznaonkologiamedycyna i nauki o zdrowiumedycyna klinicznahepatologia Program(-y) FP7-HEALTH - Specific Programme "Cooperation": Health Temat(-y) HEALTH.2010.2.4.1-4 - Infectious agents and cancer in Africa Zaproszenie do składania wniosków FP7-AFRICA-2010 Zobacz inne projekty w ramach tego zaproszenia System finansowania CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA) Koordynator IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Adres South kensington campus exhibition road SW7 2AZ London GB Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments projects.administrative_contact Tatjana Palalic (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Wkład UE € 642 000,00 Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko MEDICAL RESEARCH COUNCIL GB Wkład UE € 1 105 300,00 Adres 20 park crescent W1B 1AL London Zobacz na mapie Rodzaj działalności Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) projects.administrative_contact Tumani Corrah (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER Francja Wkład UE € 236 000,00 Adres 25 avenue tony garnier 69007 Lyon 7eme Zobacz na mapie Rodzaj działalności Research Organisations projects.administrative_contact Olaf Kelm (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francja Wkład UE € 158 000,00 Adres Rue de tolbiac 101 75654 Paris Zobacz na mapie Rodzaj działalności Research Organisations projects.administrative_contact Hiba Vergnaud (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window JOS UNIVERSITY TEACHING HOSPITAL Nigeria Wkład UE € 189 500,00 Adres Murtala mohammed way plateau state 930001 Jos Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments projects.administrative_contact Edith Okeke (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window UNIVERSITE CHEIKH ANTA DIOP DE DAKAR Senegal Wkład UE € 324 000,00 Adres Avenue martin luther king - Dakar fann Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments projects.administrative_contact Souleymane Mboup (Prof.) Linki Kontakt z organizacją Opens in new window Ministry of Health and Social Welfare Gambia Wkład UE € 137 200,00 Adres The quadrangle, banjul Banjul Zobacz na mapie Rodzaj działalności Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) projects.administrative_contact Makie Taal (Dr.) Linki Kontakt z organizacją Opens in new window XEPTAGEN SPA Włochy Wkład UE € 208 000,00 Adres Via delle industrie 9 30175 Venezia Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) projects.administrative_contact Giorgio Fassina (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window
