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Integrated research on DEvelopmental determinants of Aging and Longevity

Objective

IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human cohorts and animal studies that allow testing of hypotheses on the link between development and aging.
Key objectives of IDEAL are
1.Quantify the role of epigenetic regulation in the response to developmental conditions that affect growth & metabolism, immunity, and reproduction in animal models and its translation to human conditions.
2.Quantify the role of epigenetic regulation in the response to developmental conditions of humans and create the animal model that resembles such responses.
3.Create a reference library of gene expression and epigenetic changes as a function of age and obtain insight into principles of epigenetic regulation across species.
4.Develop monitoring tools of epigenetic effects following developmental conditions.
5.Develop monitoring tools of epigenetic control during aging and their meaning for physiological functions, and for the development of biomarkers of aging
6.Identify pathways determining and promoting human longevity.
7.Identify pathways determining human health and longevity by influencing developmental processes.
8.Develop animal models for testing relevant compounds to modify epigenetic effects early or later in life.
We will study known longevity determinants as well as newly discovered pathways, and we will link early development with all adult phases. Our research can provide models for testing interventions through epigenetic regulation that improves healthy aging and longevity and that can be translated into novel drug targets and protein therapeutics. IDEAL integrates expertise, resources and results of some of the best EU projects on ageing and has the potential to reshape health-care for a healthier and longer life in the EU.

Call for proposal

FP7-HEALTH-2010-two-stage
See other projects for this call

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 251 187,60
Administrative Contact
Karin Wibier (Ms.)

Participants (15)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 687 359,75
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Agneta Häggström (Ms.)
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 543 960
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulla Iversen (Ms.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 660 000
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emanuela Carollo (Ms.)
UNIVERSITA DELLA CALABRIA
Italy
EU contribution
€ 483 250
Address
Via Pietro Bucci 7/11/B
87036 Arcavacata Di Rende
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiziana Martino (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 1 173 468,80
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 380 286,60
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Polik (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 1 189 218
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Brice Kerber (Mr.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 630 000
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Denis Duboule (Prof.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 464 400
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Riehle (Mr.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 1 027 498,75
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yan Qiao (Ms.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 1 742 489,50
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tom Bessems
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 344 400
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Urs Meyer (Dr.)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 67 992
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ton Brouwer (Mr.)
NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S
Denmark
EU contribution
€ 100 000
Address
Herlev Hovedgade 207
2730 Helev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Nielsen (Mr.)
GENOMIC INVESTMENTS BV
Netherlands
EU contribution
€ 241 440
Address
Plesmanlaan 1D
2333 BZ Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bart Janssen (Prof.)