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Integrated research on DEvelopmental determinants of Aging and Longevity

Objective

IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human cohorts and animal studies that allow testing of hypotheses on the link between development and aging.
Key objectives of IDEAL are
1.Quantify the role of epigenetic regulation in the response to developmental conditions that affect growth & metabolism, immunity, and reproduction in animal models and its translation to human conditions.
2.Quantify the role of epigenetic regulation in the response to developmental conditions of humans and create the animal model that resembles such responses.
3.Create a reference library of gene expression and epigenetic changes as a function of age and obtain insight into principles of epigenetic regulation across species.
4.Develop monitoring tools of epigenetic effects following developmental conditions.
5.Develop monitoring tools of epigenetic control during aging and their meaning for physiological functions, and for the development of biomarkers of aging
6.Identify pathways determining and promoting human longevity.
7.Identify pathways determining human health and longevity by influencing developmental processes.
8.Develop animal models for testing relevant compounds to modify epigenetic effects early or later in life.
We will study known longevity determinants as well as newly discovered pathways, and we will link early development with all adult phases. Our research can provide models for testing interventions through epigenetic regulation that improves healthy aging and longevity and that can be translated into novel drug targets and protein therapeutics. IDEAL integrates expertise, resources and results of some of the best EU projects on ageing and has the potential to reshape health-care for a healthier and longer life in the EU.
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Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN

Address

Albinusdreef 2
2333 Za Leiden

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 251 187,60

Administrative Contact

Karin Wibier (Ms.)

Participants (15)

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KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 687 359,75

SYDDANSK UNIVERSITET

Denmark

EU Contribution

€ 543 960

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU Contribution

€ 660 000

UNIVERSITA DELLA CALABRIA

Italy

EU Contribution

€ 483 250

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 1 173 468,80

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 380 286,60

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 1 189 218

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 630 000

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU Contribution

€ 464 400

UNIVERSITY OF SOUTHAMPTON

United Kingdom

EU Contribution

€ 1 027 498,75

WAGENINGEN UNIVERSITY

Netherlands

EU Contribution

€ 1 742 489,50

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 344 400

UNIVERSITEIT LEIDEN

Netherlands

EU Contribution

€ 67 992

NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S

Denmark

EU Contribution

€ 100 000

GENOMIC INVESTMENTS BV

Netherlands

EU Contribution

€ 241 440

Project information

Grant agreement ID: 259679

Status

Closed project

  • Start date

    1 February 2011

  • End date

    31 January 2016

Funded under:

FP7-HEALTH

  • Overall budget:

    € 15 935 888,16

  • EU contribution

    € 11 986 951

Coordinated by:

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands