Obiettivo "The aim of the proposed research is to develop a new (Au-NP) gold nanoparticle-based drug delivery systems. For this new synthetic approach, three different components are designed; namely, new tailored gold nanoparticle, cleavable linkers, and new platinum-based drugs.The first component is a new tailored Au-NP, which will be synthesized using a multidentate thioether “coating ligand”. Unlike the gold nanoparticle-based nanocarriers used till date, this novel nanomaterial enables accurate functionalization of the particle surface using a multidentate ligand, allowing also controlled particle size and shape. Moreover, tuning of the gold-surface properties is easily performed by functionalization of the coating ligand, leading to a well defined drug load per particle. The functionalization also enables the attachment of linkers (second component of the system) of a programmable variety on the outer-shell of the Au-NP, which will serve as bridges between the nanocarrier and the drug.The proposed approach is the use of cleavable linkers to reach a new level of drug-controlled release. Inspired by cancer biology, peptide linkers will be attached to the coating ligand of the gold nanoparticle. These peptides will be cleaved by overexpressed proteases in cancer tissue, achieving tumor-specific drug (endogenous) release. In addition, exogenous activation of drug release using photolabile linkers will be explored, leading to new class of external controlled platinum drug release.To test this approach, platinum-based drugs (third component), which display high cure rates against several cancers (ovarian, head neck, testicular and lung cancer), will be attached to the nanocarriers using different cleavable linkers. In addition to the synthesis and characterization of these systems, in vitro studies in cancer cells will be performed to investigate their cellular processing, and establish their mechanisms of action." Campo scientifico medical and health sciencesclinical medicineoncologylung cancernatural scienceschemical sciencesinorganic chemistrytransition metalsmedical and health sciencesmedical biotechnologynanomedicineengineering and technologymaterials engineeringcoating and filmsmedical and health sciencesclinical medicineoncologyhead and neck cancer Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2010-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2010-IOF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IOF - International Outgoing Fellowships (IOF) Coordinatore UNIVERSITEIT UTRECHT Contributo UE € 228 529,60 Indirizzo HEIDELBERGLAAN 8 3584 CS Utrecht Paesi Bassi Mostra sulla mappa Regione West-Nederland Utrecht Utrecht Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Liesbeth Bos-Klomp (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
