Obiettivo "Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat solid tumors, it does not enable uniform delivery of these particles to all regions of tumors in sufficient quantities. This heterogeneous distribution of therapeutics is a result of physiological barriers presented by the abnormal tumor vasculature and interstitial matrix. These barriers are in large part responsible for the modest survival benefit offered in many cases by clinically approved nanotherapeutics and must be overcome to realize the promise of nanomedicine in patients. More specifically, we need to determine the design criteria - the size, charge and configuration of various nanoparticle platforms - that optimize drug delivery to tumors. Here, I propose the development of a mathematical framework for the delivery of therapeutic nanoparticles to solid tumors. The model will account directly for the properties of the tumor micro-environment as well as for the properties (size, charge and configuration) of nanoparticles to predict their intratumoral distribution. I will specify the model to a human sarcoma and a human mammary carcinoma cell line for which a complete set of experimental data that characterize their micro-environment exists. Informed by these experimental measurements, I will use the mathematical model to construct ""design maps"" that will predict the nanoparticle properties that optimize intratumoral delivery, and thus the efficacy of cancer therapy. I will also employ the model to investigate if modifications in the tumor micro-environment with the use of anti-angiogenic and anti-fibrotic agents can improve the distribution of nanomedicine to solid tumors." Campo scientifico medical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesclinical medicineoncologyengineering and technologynanotechnologynano-materialsnatural sciencesmathematicsapplied mathematicsmathematical model Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Invito a presentare proposte FP7-PEOPLE-2010-RG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IRG - International Re-integration Grants (IRG) Coordinatore UNIVERSITY OF CYPRUS Contributo UE € 100 000,00 Indirizzo AVENUE PANEPISTIMIOU 2109 AGLANTZI 1678 Nicosia Cipro Mostra sulla mappa Regione Κύπρος Κύπρος Κύπρος Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ioannis Giapintzakis (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
