Cel "Every third protein contains metal as cofactor. Cu-enzymes plays crucial rules in key processes in bioenergetics, mitochondrial respiration, neurotransmitter biosynthesis, antioxidation and pigmentation Therefore they are intensive targets for discovering new drugs and the understanding of their structure-functions relationships will provide new insight in translational and biomedical research.In this Marie Curie International Outgoing Fellowship I will investigate the mechanism of important two bi nuclear cupper enzyme – Peptidylglycine α-Amidating Monooxygenase (PAM) and Dopamine β-Monooxygense (DBM) which catalyze hydroxylation of substrates in crucial importance for neurobiology . The miss functionalities of these enzymes are related with nervous system disorders therefore revealing it mechanism will provide advanced opportunities for design of new drugs. In order to achieve this knowledge we will apply integrated combination of the most advanced spectroscopic techniques and state of the art computational methods." Dziedzina nauki natural sciencesbiological sciencesneurobiologynatural sciencescomputer and information sciencescomputational sciencenatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2010-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Zaproszenie do składania wniosków FP7-PEOPLE-2010-IOF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IOF - International Outgoing Fellowships (IOF) Koordynator UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE Wkład UE € 258 386,80 Adres SUTHERLAND BUILDING COLLEGE STREET NE1 8ST Newcastle Upon Tyne Zjednoczone Królestwo Zobacz na mapie Region North East (England) Northumberland and Tyne and Wear Tyneside Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Gary Black (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
