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Vaccines against helminth infections

Objective

Livestock production efficiency is impaired by helminth infection which is ubiquitous in cattle, sheep and goats world-wide. It causes severely debilitating gastro-intestinal, respiratory and hepatic disorders, dependent on the infecting species. The treatment and prevention of helminth parasitism in livestock continues to rely almost exclusively on the use of anthelmintic drugs, an approach threatened by the global emergence of anthelmintic resistance. An alternative approach is vaccination.
Members of the present consortium (from the EU and Switzerland, North and South America, North and South Africa, Australia, 2 SMEs and 1 major animal health company) have developed prototype vaccines with the predicted required efficacy to control major gastro-intestinal nematode infections of livestock, notably Ostertagia ostertagi in cattle and Haemonchus contortus in sheep, the liver fluke Fasciola hepatica in sheep and cattle with leading positions in subunit vaccine development against Cooperia onchophora, Dictyocaulus viviparus in cattle and the tapeworm Echinococcus granulosus in dogs.
This proposal aims to deliver at least one prototype vaccine to the point of uptake by the commercial sector or through government/philanthropic agencies and this will be addressed by
1) Developing effective native or synthetic vaccines, the latter using novel, molecular expression systems.
2) Defining the protective immune responses induced by these vaccines to order to optimise the structure of the antigens and the method of their delivery.
3) Defining vaccine efficacy with trials in both housed and grazing livestock
4) Providing a platform for training and knowledge exchange which includes participation in training programmes, short exchanges of staff, workshops,and web site provision.
5) Interacting closely with computer modellers, the animal health industry, farmer organisations and other stakeholders to define required vaccine characteristics.
6) Knowledge exchange/dissemination to policy makers, scientists, government departments and the general public.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

MOREDUN RESEARCH INSTITUTE

Address

Pentlands Science Park, Bush Loan
Eh26 0pz Penicuik

United Kingdom

Activity type

Research Organisations

EU Contribution

€ 878 058

Administrative Contact

Richard Mole (Dr.)

Participants (25)

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UNIVERSITEIT GENT

Belgium

EU Contribution

€ 863 482

VIB

Belgium

EU Contribution

€ 445 839

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 1 001 564

UNIVERSITE LYON 1 CLAUDE BERNARD

France

EU Contribution

€ 614 142,20

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER

Germany

EU Contribution

€ 714 845

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 293 409

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 337 021,80

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 477 996

UNIVERSIDAD DE CORDOBA

Spain

EU Contribution

€ 823 025

ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY

Canada

EU Contribution

€ 304 047,20

INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II

Morocco

EU Contribution

€ 130 875

UNIVERSIDAD DE LA REPUBLICA

Uruguay

EU Contribution

€ 100 875

AGRICULTURAL RESEARCH COUNCIL (ARC)

South Africa

EU Contribution

€ 47 675

Universidade Estadual Paulista - UNESP

Brazil

EU Contribution

€ 86 175

NOVAVAX AB

Sweden

EU Contribution

€ 97 275

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 628 425

Ecole Nationale de Médecine Vétérinaire

Tunisia

EU Contribution

€ 130 875

PFIZER LIMITED

United Kingdom

EU Contribution

€ 119 687

Lara media Limited

Ireland

EU Contribution

€ 12 455

UNIVERSIDAD NACIONAL DE CAJAMARCA

Peru

EU Contribution

€ 250 555

Triveritas Limited

United Kingdom

EU Contribution

€ 49 675

MURDOCH UNIVERSITY

Australia

EU Contribution

€ 101 675

THE QUEEN'S UNIVERSITY OF BELFAST

United Kingdom

EU Contribution

€ 272 927,80

Sokoine University of Agriculture

Tanzania

EU Contribution

€ 80 795

ZOETIS LCC

United States

EU Contribution

€ 80 811

Project information

Grant agreement ID: 265862

Status

Closed project

  • Start date

    1 April 2011

  • End date

    31 March 2015

Funded under:

FP7-KBBE

  • Overall budget:

    € 12 376 444,08

  • EU contribution

    € 8 944 185

Coordinated by:

MOREDUN RESEARCH INSTITUTE

United Kingdom