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Vaccines against helminth infections

Objective

Livestock production efficiency is impaired by helminth infection which is ubiquitous in cattle, sheep and goats world-wide. It causes severely debilitating gastro-intestinal, respiratory and hepatic disorders, dependent on the infecting species. The treatment and prevention of helminth parasitism in livestock continues to rely almost exclusively on the use of anthelmintic drugs, an approach threatened by the global emergence of anthelmintic resistance. An alternative approach is vaccination.
Members of the present consortium (from the EU and Switzerland, North and South America, North and South Africa, Australia, 2 SMEs and 1 major animal health company) have developed prototype vaccines with the predicted required efficacy to control major gastro-intestinal nematode infections of livestock, notably Ostertagia ostertagi in cattle and Haemonchus contortus in sheep, the liver fluke Fasciola hepatica in sheep and cattle with leading positions in subunit vaccine development against Cooperia onchophora, Dictyocaulus viviparus in cattle and the tapeworm Echinococcus granulosus in dogs.
This proposal aims to deliver at least one prototype vaccine to the point of uptake by the commercial sector or through government/philanthropic agencies and this will be addressed by
1) Developing effective native or synthetic vaccines, the latter using novel, molecular expression systems.
2) Defining the protective immune responses induced by these vaccines to order to optimise the structure of the antigens and the method of their delivery.
3) Defining vaccine efficacy with trials in both housed and grazing livestock
4) Providing a platform for training and knowledge exchange which includes participation in training programmes, short exchanges of staff, workshops,and web site provision.
5) Interacting closely with computer modellers, the animal health industry, farmer organisations and other stakeholders to define required vaccine characteristics.
6) Knowledge exchange/dissemination to policy makers, scientists, government departments and the general public.

Call for proposal

FP7-KBBE-2010-4
See other projects for this call

Funding Scheme

CP-IP-SICA - Large-scale integrating project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

MOREDUN RESEARCH INSTITUTE
Address
Pentlands Science Park, Bush Loan
EH26 0PZ Penicuik
United Kingdom
Activity type
Research Organisations
EU contribution
€ 878 058
Administrative Contact
Richard Mole (Dr.)

Participants (25)

UNIVERSITEIT GENT
Belgium
EU contribution
€ 863 482
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margo Baele (Dr.)
VIB VZW
Belgium
EU contribution
€ 445 839
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 1 001 564
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Grace Mulcahy (Prof.)
UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 614 142,20
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javier Olaiz (Dr.)
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 714 845
Address
Bunteweg 2
30559 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Joppe (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 293 409
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cornelis Hendrik Hokke (Dr.)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 337 021,80
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 477 996
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Veronica Shaw (Ms.)
UNIVERSIDAD DE CORDOBA
Spain
EU contribution
€ 823 025
Address
Avenida De Medina Azahara 5
14005 Cordoba
Activity type
Higher or Secondary Education Establishments
Administrative Contact
José Pérez (Prof.)
ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY
Canada
EU contribution
€ 304 047,20
Address
845 Sherbrooke Street West
H3A0G4 Montreal
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Olga Naiberguer (Ms.)
INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II
Morocco
EU contribution
€ 130 875
Address
Avenue Allal El Fassi Madinat Al
10101 Rabat
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mohamed Iqbal Jazouli (Mr.)
UNIVERSIDAD DE LA REPUBLICA
Uruguay
EU contribution
€ 100 875
Address
Avenida 18 De Julio 1824
11200 Montevideo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lorena Vazquez (Ms.)
AGRICULTURAL RESEARCH COUNCIL INSTITUTE FOR SOIL CLIMATE AND WATER
South Africa
EU contribution
€ 47 675
Address
Belvedere Street 600
0001 Pretoria
Activity type
Research Organisations
Administrative Contact
Andries Pretorius (Mr.)
UNIVERSIDADE ESTADUAL PAULISTA JULIO DE MESQUITA FILHO
Brazil
EU contribution
€ 86 175
Address
Quirino De Andrade 215
0149010 Sao Paulo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alessandro Amarante (Prof.)
NOVAVAX AB
Sweden
EU contribution
€ 97 275
Address
Kungsgatan 109
753 18 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bobby Lodin (Mr.)
University of Zurich
Switzerland
EU contribution
€ 628 425
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Deplazes (Prof.)
Ecole Nationale de Médecine Vétérinaire
Tunisia
EU contribution
€ 130 875
Address
Avenue Habib Bourguiba
2020 Sidi Thabet
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Samia Lahmar (Prof.)
PFIZER LIMITED

Participation ended

United Kingdom
EU contribution
€ 119 687
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Fraser Stewart (Dr.)
Lara media Limited
Ireland
EU contribution
€ 12 455
Address
Iveragh Road Whitehall 98
9 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gerald Cannon (Mr.)
UNIVERSIDAD NACIONAL DE CAJAMARCA
Peru
EU contribution
€ 250 555
Address
Av. Atahualpa 1050
Cajamarca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pedro Ortiz (Dr.)
Triveritas Limited
United Kingdom
EU contribution
€ 49 675
Address
Bank Barn How Mill 1
CA8 9JY Brampton
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Julian Braidwood (Mr.)
MURDOCH UNIVERSITY
Australia
EU contribution
€ 101 675
Address
South Street 90
6150 Murdoch Perth
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Leylani Taylor (Ms.)
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 272 927,80
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ronan Crossey (Mr.)
Sokoine University of Agriculture
Tanzania
EU contribution
€ 80 795
Address
Sokoine University Of Agriculture
Morogoro
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karimuribo Esrony (Prof.)
ZOETIS LCC
United States
EU contribution
€ 80 811
Address
1209 Orange Street
19801 Wilmington Delaware
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Geurden (Dr.)