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Photoresponsive multifunctional DNA block copolymer nanocarriers for drug delivery and vaccine development

Objective

Cancer treatment and vaccine development represent two of the major challenges that contemporary medicine is confronted with. Although significant progress has been achieved in both fields, the present methodologies remain limited, in part due to the numerous specific requirements for each treatment. This proposal focuses on the development of a novel, versatile drug delivery system suitable for either purpose, combining multifunctionality and controlled molecular release using biocompatible materials. The proposed approach involves the use of self-assembled nanocarriers based on amphiphilic DNA block copolymers with a photodegradable linker (PL) as a junction point (DNA-PL-Pol). These nanocarriers combine the advantageous features of the constituents of the DNA-PL-Pol, i.e. the possibility of attaching multiple functionalities by DNA hybridization, the localized and controlled release of encapsulants by near-infrared irradiation (NIR) and the biodegradability of the polymers. The project involves on one hand the synthesis of DNA-PL-Pol and the study of their aggregation behavior and on the other hand, the testing of the systems in cancer treatment and vaccine development. The proposed work will cover diverse fields in scientific research, i.e. organic and polymer synthesis, physical organic chemistry, supramolecular chemistry, biochemistry, cancer therapy and immunology.
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Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Address

Batiment Ce 3316 Station 1
1015 Lausanne

Switzerland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 236 283,60

Administrative Contact

Jeffrey Hubbell (Prof.)

Project information

Grant agreement ID: 274717

Status

Closed project

  • Start date

    1 July 2011

  • End date

    30 June 2014

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 236 283,60

  • EU contribution

    € 236 283,60

Coordinated by:

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland