Objectif "Our proposal will tackle a central issue in biology: what is the genetic basis of species differentiation? Recent evidence of genetic exchange among species has led many to reject the traditional view that speciation requires complete reproductive isolation. Instead, the emerging new concept of so-called ‘genic speciation’ asserts that reproductive barriers can be established by divergence at only a few loci against a background of gene flow. We will combine novel and powerful analytical methods with new and traditional genetic technologies to investigate the genetic basis of species differences, and the process of divergence, in a model system of two co-distributed species of horseshoe bat (R. yunanensis and R. p. pearsoni). The Incoming Fellow has previously shown that, in these taxa, there is strong evidence of extensive past replacement of the nuclear genome in spite of clear phenotypic, acoustic and karyotypic differences. This unusual system provides an exceptional opportunity to identify and characterize genes that encode phenotypic differences among taxa, and also to determine the functional characteristics of ‘leaky genes’ versus ‘non-leaky genes’ (or ‘species genes’). Such knowledge of a natural mammalian system at a genome scale would take us beyond the current state-of-the art of research in this field, and would have impact in frontier science as well as potential benefits to conservation, genetics and evolutionary biologists. We will use Next Generation Sequencing and a highly novel statistical pipeline to identify key loci and larger ‘genomic islands’ that have resisted introgressive hybridization between our focal taxa. Our phylogenomic approach will then be extended to a larger sample to study whether these loci are under selection. Finally, we will apply chromosomal genetics methods to establish whether non-leaky loci and islands are influenced by the presence of chromosomal rearrangements, such as inversions." Champ scientifique natural sciencesbiological sciencesgeneticsgenomes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2010-IIF - Marie Curie Action: "International Incoming Fellowships" Appel à propositions FP7-PEOPLE-2010-IIF Voir d’autres projets de cet appel Régime de financement MC-IIF - International Incoming Fellowships (IIF) Coordinateur QUEEN MARY UNIVERSITY OF LONDON Contribution de l’UE € 210 092,80 Adresse 327 MILE END ROAD E1 4NS London Royaume-Uni Voir sur la carte Région London Inner London — East Tower Hamlets Type d’activité Higher or Secondary Education Establishments Contact administratif Stephen Rossiter (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée