Cel An important feature of human cognition is its remarkable flexibility. Cognitive control refers to processes that allow behaviour to vary adaptively depending on current goals. Understanding it is therefore fundamental to knowing how our behaviour can be adapted and flexible. Deficits in cognitive control, and imbalances in related neurotransmitters such as dopamine, are associated with a number of psychological and neurological conditions, including schizophrenia and the cognitive symptoms of Parkinson’s disease. Both prefrontal cortex (PFC) and anterior cingulate cortex (ACC) are known to have important roles in cognitive control, but the details of how they achieve this, how they interact, and the roles of those neurotransmitters are unclear. An important way to discover this is to record the effects of inactivating those regions and neurotransmitter systems, as this reveals how these systems are critical to cognition.This project will reveal the nature of the frontal lobe interactions that subserve cognitive control, and their neurochemical basis, by combining inactivation and neurophysiological techniques.In macaque monkeys performing a well-established test of multiple elements of cognitive control, we will reversibly inactivate targeted regions of ACC and PFC whilst simultaneously recording continuous neurophysiological data using chronically implanted electroencephalography. We will go on to record the same data during reversible localized blockade of targeted neurotransmitter systems, beginning with dopamine, and then to functionally disconnect ACC and PFC.The project will have significant benefits for both fundamental and clinical research, and represents a rare combination of techniques made possible by mobility between laboratories. It will substantially enhance the career of the researcher. Dziedzina nauki medical and health sciencesbasic medicineneurologyparkinsonmedical and health sciencesclinical medicinepsychiatryschizophrenia Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2010-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Wkład UE € 185 748,00 Adres RUE DE TOLBIAC 101 75654 Paris Francja Zobacz na mapie Region Ile-de-France Ile-de-France Paris Rodzaj działalności Research Organisations Kontakt administracyjny Dominique Pella (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
