Objetivo "Obesity and lipoatrophy are characterised by excess and paucity respectively of white adipose tissue. Both associated with insulin resistance, diabetes and cardiovascular disease, their prevalence will exceed 1 billion people by 2030. The convergence in metabolic phenotype of these two disparate disorders highlights how a precisely controlled, metabolically active adipose tissue is essential for proper health.Polycomb/Trithorax group (PcG/Trx) proteins were first identified in D. melanogaster as modulators of developmental patterning genes and are now recognized as fundamental executors of a chromatin-based silencing system that, capable of activating or silencing entire gene sets, is critical for multicellular development, differentiation and stem cell turnover. One of the most interesting features of PcG-induced gene-silencing patterns is to be transmitted through multiple cell divisions, thus touting them as mediators of cellular memory and critical to the stabilities of virtually all cell fates. Recent findings suggest a robust potential of PcG proteins to downregulate key developmental pathways involved in adipogenesis and adipose tissue function.Here we aim to define the role of PcG/Trx proteins in adipose tissue development, maintenance and function in vivo. This will be achieved by a multi-faceted approach including 1.functional characterization of temporally-inducible adipose tissue-specific PcG/Trx knock-out mice, 2.parallel profiling of gene expression, chromatin state, and PcG binding in mice and in highly characterized human samples from control and metabolically diseased patients, and 3.determination of mechanism through gain and loss-of-function approaches in vitro.Our plan merges the power of inducible gene targeting in mice with human genetics and disease biology. These approaches will help us understanding the role of chromatin remodeling in steady-state adipose tissue function and provide first hints at its contribution towards human disease." Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesbasic medicinemedical geneticsmedical and health scienceshealth sciencesnutritionobesity Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2010-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Aportación de la UE € 162 242,40 Dirección HOFGARTENSTRASSE 8 80539 Munchen Alemania Ver en el mapa Región Bayern Oberbayern München, Kreisfreie Stadt Tipo de actividad Research Organisations Contacto administrativo Patrice Wegener (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
