Oxidative and Inflammatory Response of Oysters to Harmful Algal Bloom Species

Projektinformationen

OXIREHAB

ID Finanzhilfevereinbarung: 272869

Abgeschlossenes Projekt

Startdatum 1 August 2011

Enddatum 31 Juli 2014

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 239 034,40

EU-Beitrag € 239 034,40

Koordiniert durch

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Ziel

Harmful Algal blooms (HABs) are a global issue with economic, ecologic and biomedical implications. Shellfish mortalities associated with HABs have been observed. Algal toxins accumulate in some bivalves whereas other species won't display similar accumulation. Furthermore, one species may respond differentially to various toxins, which causes difficulties to generalize the mechanisms involved. Only very few studies investigated cellular and molecular mechanisms occurring during HAB exposure. Exposure of bivalves to HABs may induce an inflammatory response involving hemocytes and oxidative activity. The need to understand cellular and molecular mechanisms during the response of bivalves to HABs appears necessary. At the cellular level, hemocytes may play primordial role. At the molecular level, oxidative stresses might be of extreme importance. The objectives of this project are to characterise the cellular and molecular inflammatory responses and oxidative activities of oysters to HAB exposure, and the potential involvement of hemocytes in transportation of toxin. In vivo exposures and oysters collected in situ during algal blooms will allow the evaluation of inflammatory response, oxidative and anti-oxidant activities, and localisation of algal toxins in the tissues. In vitro experiments will help to assess the interactions between hemocytes and algal cells, and cellular and molecular mechanisms directing the response, as well as the capacity of hemocytes to acquire and depurate the algal toxins. Gathering in vitro and in vivo / in situ results will provide understanding of the cellular and molecular events taking place during bivalve exposure to HABs. Such knowledge will help determine which are the key phenomena leading to toxin accumulation or detoxification. This research will allow to further investigate how the physiological state of bivalves can influence toxin accumulation, and will provide information for shellfish aquaculture, restoration and management.

Wissenschaftliches Gebiet

• agricultural sciences › agriculture, forestry, and fisheries › fisheries
• social sciences › sociology › demography › mortality

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2010-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2010-IOF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IOF - International Outgoing Fellowships (IOF)

Koordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Kontakt Verwaltung

Anne Fagon (Ms.)

• EU-Beitrag: € 239 034,40
• Adresse: RUE MICHEL ANGE 3 ; 75794 Paris ; Frankreich
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten