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Synthesis and characterization of NANOstructured materials with LumInescent properties for diaGnostic and tHerapeuTic applications

Objetivo

"The aim of the present project is to explore different synthesis strategies to obtain silicon nanocrystals and carbon nanodots with luminescent properties as alternative to conventional fluorescent biomarkers or other light-emitting semiconductor nanoparticles containing heavy metals known as quantum dots. Nanostructured silicon can provide appealing properties such as size and wavelength-dependent luminescence emission in the red/near infrared window, resistance to photobleaching, and robust surface chemistry for grafting of bio-molecules without incurring the burden of intrinsic toxicity or elemental scarcity of quantum dots. Carbon-based nanostructures with fluorescent properties remain relatively unexplored but similar behaviour and properties can be envisaged.

The production of silicon nanocrystals will be approached by means of two different methods: i) thermal processing of silesquioxanes to produce an encapsulating oxide matrix for the silicon nanocrystals and ii) laser pyrolysis of silicon precursors either in gas phase or in the form of aerosols containing organometallic precursors. Both methods are quite novel and offer great possibilities for scaling up the batch production of silicon nanocrystals offered by current methodologies. Likewise, the synthesis of carbon nanodots will be explored by both thermal decomposition and laser ablation of carbon-containing precursors.

To stabilize the nanoparticles and render them biocompatible for in vitro and in vivo diagnostic imaging experiments, different passivating and encapsulating agents like alkyl or alkoxy-groups and micelle-forming polymers and phospholipids will be evaluated. Finally, fluorescent labelling of cells, evaluation of cytotoxicity, drug-loading, circulation and degradation of selected samples will be carried out."

Ámbito científico

  • /ciencias naturales/ciencias químicas/química inorgánica/compuestos inorgánicos
  • /ingeniería y tecnología/nanotecnología/nanomateriales/nanocristal
  • /ciencias naturales/ciencias físicas/electromagnetismo y electrónica/conductividad eléctrica/semiconductor
  • /ciencias naturales/ciencias químicas/ciencia de polímeros
  • /ciencias naturales/ciencias físicas/óptica/física del láser

Convocatoria de propuestas

FP7-PEOPLE-2011-CIG
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Régimen de financiación

MC-CIG - Support for training and career development of researcher (CIG)

Coordinador

UNIVERSIDAD DE ZARAGOZA
Dirección
Calle Pedro Cerbuna 12
50009 Zaragoza
España
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 75 000
Contacto administrativo
Oscar Lopez Lorente (Mr.)