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The lab-free CBRN detection device for the identification of biological pathogens on nucleic acid and immunological level as lab-on-a-chip system applying multisensor technologies

Objective

The goal of MultiSENSE is the development of a detection and identification system for biological pathogens, which shall include both the sample preparation stage, during which target molecules are extracted directly and in parallel the ensuing nucleic-acid-based and/or immunological detection and identification steps, in order to build an integrated “sample in, result out” system. Disruptive technologies (e.g., advanced sensor technologies like optoelectronic sensors or electrochemical sensors), lab-on-chip technology, and innovative instrumentation are key to reaching the presently unrealized goal of identifying pathogens in parallel on both the molecular biology level via PCR and the immunological route.
The chosen technologies offer several advantages: on the one hand, a small, portable, and easy-to-use device can be realized due to miniaturization; on the other, the so-called lab-on-chip technology enables operation outside of lab settings, meaning that the complete analysis including sample preparation, extraction of target molecules, etc. will be carried out in a small device the size of a microtiter plate with all necessary reagents on board. This includes dry reagent storage of lysis reagents, master mixes for the PCR, antibodies, and liquid storage of buffers. Furthermore, it will be imperative that an on-chip waste storage be included in order to eliminate contamination risk. The overall target is a “sample in, result out”-type handling procedure.
A reduction of processing times is a further advantage owed to miniaturization and the combination of all biological processes in a small disposable chip instead of different instruments. Finally, suitably equipped biological laboratories are no longer necessary to run PCR and immunological assays as portable systems may instead be used to analyze suspicious samples directly at the point of interest. Sensor technology will be another enabling technology we will apply.

Field of science

  • /natural sciences/biological sciences/molecular biology
  • /engineering and technology/electrical engineering, electronic engineering, information engineering/electronic engineering/sensors
  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid

Call for proposal

FP7-SEC-2010-1
See other projects for this call

Funding Scheme

CP - Collaborative project (generic)

Coordinator

MICROFLUIDIC CHIPSHOP GMBH
Address
Stockholmer Strasse 20
07747 Jena
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 2 133 828,08
Administrative Contact
Claudia Gärtner (Dr.)

Participants (8)

INSTITUT FUER MIKROTECHNIK MAINZ GMBH

Participation ended

Germany
Address
Carl-zeiss-str. 18-20
55129 Mainz
Activity type
Research Organisations
Administrative Contact
Frank Hainel (Dr.)
BERTIN TECHNOLOGIES SAS
France
EU contribution
€ 462 157,50
Address
Av Ampere, Parc Activ Pas Du Lac 10B
78180 Montigny Le Bretonneux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
William Vivien (Mr.)
FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT
Germany
EU contribution
€ 691 980
Address
Sudufer 10
17493 Greifswald-insel Riems
Activity type
Research Organisations
Administrative Contact
Franziska Kammann (Ms.)
IMICROQ SL
Spain
EU contribution
€ 473 856
Address
Calle Ferro 6 Nave 7 Poligon Industrial Riu Clar
43006 Tarragona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carlos Arias (Mr.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 1 411 933,50
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Andrea Zeumann (Ms.)
UNIVERSITAT ROVIRA I VIRGILI
Spain
EU contribution
€ 714 502,92
Address
Carrer De Escorxador
43003 Tarragona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rosa Solà I Alberich (Prof.)
INSTITUT ZA FIZIKALNO BIOLOGIJO D.O.O.

Participation ended

Slovenia
EU contribution
€ 242 781,50
Address
Toplarniska Ulica 19
1000 Ljubljana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexis Zrimec (Dr.)
CEDRALIS SAS
France
EU contribution
€ 488 360
Address
Rue Jean Jaures -Tour Litwin- 10
92800 Puteaux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Delphine Arias-Buffard (Ms.)