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A BLUEPRINT of Haematopoietic Epigenomes

Objective

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and on their malignant leukaemic counterparts. Reference epigenomes will be generated by state-of-the-art technologies from highly purified cells for a comprehensive set of epigenetic marks in accordance with quality standards set by IHEC. This resource-generating activity will be conducted at dedicated centres to be complemented by confederated hypothesis-driven research into blood-based diseases, including common leukaemias and autoimmune disease (T1D), by epigenetic targets and compound identification, and by discovery and validation of epigenetic markers for diagnostic use. By focussing on 100 samples of known genetic variation BLUEPRINT will complete an epigenome-wide association study, maximizing the biomedical relevance of the reference epigenomes. Key to the success of BLUEPRINT will be the integration with other data sources (i.e. ICGC, 1000 genomes and ENCODE), comprehensive bioinformatic analysis, and user-friendly dissemination to the wider scientific community. The involvement of innovative companies will energize epigenomic research in the private sector by creating new targets for compounds and the development of smart technologies for better diagnostic tests. BLUEPRINT will outreach through a network of associated members and form critical alliances with leading networks in genomics and epigenomics within Europe and worldwide. Through its interdisciplinarity and scientific excellence combined with its strong commitment to networking, training and communication BLUEPRINT strives to become the cornerstone of the EU contribution to IHEC.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-HEALTH-2011-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 5 108 118,63
Administrative Contact
Marion Bussemakers (Dr.)

Participants (44)

HALO GENOMICS AB

Participation ended

Sweden
EU contribution
€ 269 752,80
Address
Dag Hammarskjolds Vag 36B
75183 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olle Ericsson (Dr.)
CELLZOME AG

Participation ended

Germany
EU contribution
€ 1 214 400
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Reinhard Markus (Mr.)
University College London
United Kingdom
EU contribution
€ 846 436
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 3 748 476,60
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms.)
Novartis Forschungsstiftung
Switzerland
EU contribution
€ 85 763,56
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
Administrative Contact
Dorothy Searles (Ms.)
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 475 080
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susanne Neufeldt (Ms.)
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
EU contribution
€ 670 600
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Laura Bertolini (Ms.)
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
EU contribution
€ 631 400
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ilaria Foti (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 799 209,60
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Tom Ratcliff (Mr.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 573 766,60
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
David Davison (Mr.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
EU contribution
€ 359 999,68
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Activity type
Research Organisations
Administrative Contact
Anaïs Desclos (Ms.)
FUNDACIO PARC CIENTIFIC DE BARCELONA
Spain
EU contribution
€ 1 880 000
Address
Baldiri I Reixac 4
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Moises Tarté (Mr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 986 000
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
Martin Vingron (Prof.)
UNIVERSITAT DES SAARLANDES
Germany
EU contribution
€ 351 600
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Melanie Paulus (Ms.)
UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI
Italy
EU contribution
€ 612 987,60
Address
Viale Abramo Lincoln 5
81100 Caserta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Annunziata Valente (Dr.)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 1 761 800
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Mariana Morlans (Ms.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 1 171 066
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Szendeffy Tanya (Ms.)
THE BABRAHAM INSTITUTE
United Kingdom
EU contribution
€ 475 932,25
Address
Babraham Hall
CB22 3AT Cambridge
Activity type
Research Organisations
Administrative Contact
Caroline Edmonds (Dr.)
CELLZOME GMBH
Germany
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Reinhard Markus (Mr.)
DIAGENODE
Belgium
EU contribution
€ 557 520
Address
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Léon Etienne (Mr.)
AGILENT TECHNOLOGIES SWEDEN AB

Participation ended

Sweden
EU contribution
€ 21 601,50
Address
Kronborgsgrand 23
SE16494 Kista
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olle Ericsson (Dr.)
Genomatix Software GmbH
Germany
EU contribution
€ 897 600
Address
Bayerstrasse 85A
80335 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Seifert (Dr.)
OXFORD NANOPORE TECHNOLOGIES LTD
United Kingdom
Address
Robert Robinson Avenue - Oxford Science Park 4
OX4 4GA Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jim Mcdonald (Mr.)
SIENA BIOTECH SPA

Participation ended

Italy
EU contribution
€ 40 248,41
Address
Via Fiorentina 1
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Antonio Chiumiento (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 339 465,60
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Dominique Nobile (Mr.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 891 176,80
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Nathalie Villahoz (Ms.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 360 640,80
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 252 100
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Van Zeijl (Ms.)
UNIVERSITAET ULM
Germany
EU contribution
€ 208 800
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 7 500
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helen New (Ms.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 92 250
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mattias Brattström (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 600 000
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 242 379,60
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Antonello Mai (Prof.)
VIVIA BIOTECH S.L.

Participation ended

Spain
EU contribution
€ 76 411,08
Address
C Santiago Grisolia 2 Oficina 205
28760 Tres Cantos Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sergio Garcia (Mr.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 199 800
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stylianos E. Antonarakis (Prof.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 286 800
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerda Klooster (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 60 019,20
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Franck Charron (Mr.)
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 99 200,40
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lita Plaumann (Ms.)
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 124 400
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard Fuchs (Mr.)
BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION
Spain
EU contribution
€ 212 486,40
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Research Organisations
Administrative Contact
Guadalupe Moreno Beltrán (Ms.)
SIGOLIS AB

Participation ended

Sweden
EU contribution
€ 110 656,80
Address
Dag Hammarskjolds Vag 58A
752 37 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jonas Jarvius (Dr.)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 350 150
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Melanie Paulus (Ms.)
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Austria
EU contribution
€ 654 264,85
Address
Lazarettgasse 14 Akh Bt 25.3
1090 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Angelika Eisner (Ms.)
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland
EU contribution
€ 288 803,24
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
Administrative Contact
Dorothy Searles (Mrs.)