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A BLUEPRINT of Haematopoietic Epigenomes

A BLUEPRINT of Haematopoietic Epigenomes

Objective

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and on their malignant leukaemic counterparts. Reference epigenomes will be generated by state-of-the-art technologies from highly purified cells for a comprehensive set of epigenetic marks in accordance with quality standards set by IHEC. This resource-generating activity will be conducted at dedicated centres to be complemented by confederated hypothesis-driven research into blood-based diseases, including common leukaemias and autoimmune disease (T1D), by epigenetic targets and compound identification, and by discovery and validation of epigenetic markers for diagnostic use. By focussing on 100 samples of known genetic variation BLUEPRINT will complete an epigenome-wide association study, maximizing the biomedical relevance of the reference epigenomes. Key to the success of BLUEPRINT will be the integration with other data sources (i.e. ICGC, 1000 genomes and ENCODE), comprehensive bioinformatic analysis, and user-friendly dissemination to the wider scientific community. The involvement of innovative companies will energize epigenomic research in the private sector by creating new targets for compounds and the development of smart technologies for better diagnostic tests. BLUEPRINT will outreach through a network of associated members and form critical alliances with leading networks in genomics and epigenomics within Europe and worldwide. Through its interdisciplinarity and scientific excellence combined with its strong commitment to networking, training and communication BLUEPRINT strives to become the cornerstone of the EU contribution to IHEC.
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Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 5 108 118,63

Administrative Contact

Marion Bussemakers (Dr.)

Participants (44)

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HALO GENOMICS AB

Sweden

EU Contribution

€ 269 752,80

CELLZOME AG

Germany

EU Contribution

€ 1 214 400

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 846 436

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 3 748 476,60

Novartis Forschungsstiftung

Switzerland

EU Contribution

€ 85 763,56

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Germany

EU Contribution

€ 475 080

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

Spain

EU Contribution

€ 670 600

ISTITUTO EUROPEO DI ONCOLOGIA SRL

Italy

EU Contribution

€ 631 400

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 1 799 209,60

GENOME RESEARCH LIMITED

United Kingdom

EU Contribution

€ 573 766,60

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Spain

EU Contribution

€ 359 999,68

FUNDACIO PARC CIENTIFIC DE BARCELONA

Spain

EU Contribution

€ 1 880 000

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 986 000

UNIVERSITAT DES SAARLANDES

Germany

EU Contribution

€ 351 600

UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI

Italy

EU Contribution

€ 612 987,60

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

EU Contribution

€ 1 761 800

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

EU Contribution

€ 1 171 066

THE BABRAHAM INSTITUTE

United Kingdom

EU Contribution

€ 475 932,25

CELLZOME GMBH

Germany

DIAGENODE

Belgium

EU Contribution

€ 557 520

AGILENT TECHNOLOGIES SWEDEN AB

Sweden

EU Contribution

€ 21 601,50

Genomatix Software GmbH

Germany

EU Contribution

€ 897 600

OXFORD NANOPORE TECHNOLOGIES LTD

United Kingdom

SIENA BIOTECH SPA

Italy

EU Contribution

€ 40 248,41

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 339 465,60

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU Contribution

€ 891 176,80

WEIZMANN INSTITUTE OF SCIENCE

Israel

EU Contribution

€ 360 640,80

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 252 100

UNIVERSITAET ULM

Germany

EU Contribution

€ 208 800

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 7 500

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 92 250

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 600 000

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy

EU Contribution

€ 242 379,60

VIVIA BIOTECH S.L.

Spain

EU Contribution

€ 76 411,08

UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 199 800

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 286 800

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 60 019,20

UNIVERSITAETSKLINIKUM ESSEN

Germany

EU Contribution

€ 99 200,40

UNIVERSITAET LEIPZIG

Germany

EU Contribution

€ 124 400

BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION

Spain

EU Contribution

€ 212 486,40

SIGOLIS AB

Sweden

EU Contribution

€ 110 656,80

EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH

Germany

EU Contribution

€ 350 150

CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH

Austria

EU Contribution

€ 654 264,85

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION

Switzerland

EU Contribution

€ 288 803,24

Project information

Grant agreement ID: 282510

Status

Closed project

  • Start date

    1 October 2011

  • End date

    30 September 2016

Funded under:

FP7-HEALTH

  • Overall budget:

    € 39 664 716,88

  • EU contribution

    € 29 996 664

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands