Cel The objective of this research plan is to develop mathematical foundations and geometric computational algorithms to bio-mimetically model fully customized and complex three-dimensional (3D) heterogeneous (multi-material) structures with controlled material composition and distribution. The proposed work will be used to model active multi-functional porous structures with controlled micro-architecture to satisfy different and sometimes conflicting functional requirements.First, computational algorithms are proposed to optimally design multi-material with bio-active molecules spatially in porous structures. A new design methodology is proposed to relate material and bioactive distribution to 3D shape (geometry). The internal micro-architecture of porous structures is also optimized based on biological and mechanical requirements. Second, a novel bio-fabrication processed is proposed to fabricate designed multi-functional active porous structures with various biodegradable materials embedded with active bio-molecules directly from the computer models. The proposed methodologies will be applied to 3D tissue scaffolds. Cell migration into design 3D scaffold will be tested in-vitro to assess and optimize the proposed methodologies. The proposed methods will make more advanced active scaffold systems possible. These active multi-functional porous structures could be used to arrange cells in an appropriate 3D configuration and present molecular signals in a spatial and temporal fashion so that the individual cells will grow and form the desired tissue structures.The results from this research would enable use of active implants, tissue/organ substitutes and micro-scale bio-sensors in many new applications in medicine and biomedical engineering. This project will also advance the knowledge in heterogeneous object modelling in computer-aided design, layered-based fabrication methodologies and biomaterials. Dziedzina nauki engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsnatural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencesmathematicspure mathematicsgeometryengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesmedical biotechnologyimplants Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Zaproszenie do składania wniosków FP7-PEOPLE-2011-CIG Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-CIG - Support for training and career development of researcher (CIG) Koordynator SABANCI UNIVERSITESI Wkład UE € 75 000,00 Adres ORTA MAHALLE UNIVERSITE CADDESI N 27 TUZLA 34956 Istanbul Turcja Zobacz na mapie Region İstanbul İstanbul İstanbul Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Aslihan Eran (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
