Cel This research aims to understand how inflammatory cues regulate the cellular responses of different cells implicated in inflammation. The main hypothesis is that non-muscle myosin II (NMII) is a central integrator of the different types of extracellular signals produced during the inflammatory response. The precise goal of the present proposal is to understand the regulation and function of the three NMII isoforms in the migration of cells implicated in inflammation, chiefly blood immune cells and cells that drive tissue repair and remodelling (fibroblasts) and vascularization (endothelial cells). This research will address the following objectives: 1) Identify specific kinases, phosphatases and regulatory sites that regulate NMII activation and assembly in a cell type-, stimulus-, isoform- and spatiotemporal-dependent manner. 2) Determine the signalling events and pathways through which the NMII isoforms control the response to inflammatory cues. 3) Elucidate whether the differences in expression and regulation of NMII underlie the different roles of these cells during inflammation. Successful completion of these objectives will provide novel insights on the basic cellular mechanisms of inflammation and bears potential to identify new therapeutic targets. Dziedzina nauki medical and health sciencesbasic medicineimmunology Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Zaproszenie do składania wniosków FP7-PEOPLE-2011-CIG Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-CIG - Support for training and career development of researcher (CIG) Koordynator UNIVERSIDAD AUTONOMA DE MADRID Wkład UE € 100 000,00 Adres CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO 28049 Madrid Hiszpania Zobacz na mapie Region Comunidad de Madrid Comunidad de Madrid Madrid Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Mª Carmen Puerta (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
