Objectif "A key principle in the evolutionary ecology of disease is the degree to which hosts invest in defence against parasites and pathogens. Established concepts in this area include (1) that disease risk is a function of host density and (2) that risk of disease leads to selection on the host to minimize the potential costs of disease. A clear prediction that arises from these concepts is that hosts living at high densities should invest more in defence than those living at low densities: a hypothesis known as “positive density-dependent prophylaxis” (DDP). For the past three years I have studied the African armyworm system (Spodoptera exempta), a devastating crop pest which expresses an extreme form of density-dependent phenotypic plasticity positive-DDP in response to host crowding. An equally destructive agricultural pest, the Australian Plague Locust (APL), Chortoicetes terminifera, has been suggested to exhibit “negative-DDP”, with certain key immune functions shown to be lower in gregarious than in the solitary insects. This project will attempt to determine why species with similar migratory activity appear to have evolved contrary behavioural and immunological strategies to combat disease transmission. The APL is an ideal model system to study the effects of crowding and migration, occurring in a socio-politically stable continent, allowing state-of-the-art field and laboratory experimentation. I will use my knowledge of migratory host-pathogen dynamics and expertise in experimental biology to investigate three main objectives, a) to determine the spatial and temporal pattern of natural disease epizootics in APL populations, b) to compare immune function and disease resistance in gregarious and solitary locusts, and c) to quantify the impact of protein availability on immune function, host behaviour and disease resistance. This research will contribute to the knowledge-base in global food security and nutrition biology." Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesnutritionnatural sciencesbiological sciencesecologyevolutionary ecologyagricultural sciencesagriculture, forestry, and fisheriesagriculturenatural sciencesbiological scienceszoologyentomology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2010-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2010-IOF Voir d’autres projets de cet appel Régime de financement MC-IOF - International Outgoing Fellowships (IOF) Coordinateur UNIVERSITY OF LANCASTER Contribution de l’UE € 268 824,80 Adresse BAILRIGG LA1 4YW Lancaster Royaume-Uni Voir sur la carte Région North West (England) Lancashire Lancaster and Wyre Type d’activité Higher or Secondary Education Establishments Contact administratif Sarah Taylor (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
