Cel In the past 20 years, we have witnessed a constant rise in bacterial resistance to antibiotics. Paradoxically, this has been accompanied by an almost complete exodus of pharmaceutical companies from the antibiotics market. As a result we are facing a situation where our antibacterial toolkit is much depleted and outdated. The goal of the proposed research is to address this deficiency by studying a group of potentially promising novel antibiotic targets: ATP Binding Cassette (ABC) transporters of transition metals.In many clinically important bacterial pathogens (e.g. Streptococcus pneumonia, Mycobacterium tuberculosis, Salmonella typhi) ABC transporters of transition metals have been shown to be essential for virulence/pathogenesis. Remarkably, beyond these observations, little else is known of these systems. We propose to study, and develop inhibitors towards 3 uncharacterized transition metal ABC transport systems that are essential to pathogenesis: ZnuABC of Salmonella typhi, sloABC of Streptococcus pneumonia, and the newly identified Bacillus anthracis (Anthrax) virulence determinant MntABC.Our proposal is comprised of two parts: the first is an in-depth functional analysis of these transporters, aimed at understanding their molecular mechanism. Our second goal, which is inseparable from the first, is to develop inhibitors for these transport systems, laying the foundations for future antibiotic development. Dziedzina nauki medical and health sciencesclinical medicinepneumologynatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysis Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Zaproszenie do składania wniosków FP7-PEOPLE-2011-CIG Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-CIG - Support for training and career development of researcher (CIG) Koordynator TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Wkład UE € 100 000,00 Adres SENATE BUILDING TECHNION CITY 32000 Haifa Izrael Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Mark Davison (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
