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ID: BMH4951561
Start date: 1996-01-01, End date: 1998-12-31
- To conduct a clinical trial on beta cell transplantation in diabetic patients with the purpose of identifying graft and recipient conditions which favour survival of beta cell allograft prepared from donor pancreata. - To develop alternative sources for beta cell grafts wit...
Programme: FP4-BIOMED 2
Record Number: 30907
Last updated on: 2001-12-07
ID: BMH4972717
Start date: 1997-09-01, End date: 2000-08-31
A major cause of high circulating levels of glucose in non insulin-dependent diabetes mellitus (NIDDM) is the insulin resistance of skeletal muscle. Since muscle is the prime tissue for glucose disposal, the impairment of insulin-stimulated muscle glucose uptake is considered ...
Programme: FP4-BIOMED 2
Record Number: 37771
Last updated on: 2002-04-22
ID: BMH4972640
Start date: 1997-05-01, End date: 2000-04-30
- To apply drug- and concentration-effect modelling to all phases of a clinical drug development program with the specific objective of integrating information obtained from preclinical and clinical studies so that rational choices of dosage regimens can be made at each stage ...
Programme: FP4-BIOMED 2
Record Number: 36417
Last updated on: 2002-04-22
ID: BMH4960254
Start date: 1996-06-01, End date: 1999-05-31
To integrate in vitro tests or models, based on human liver-derived systems. for predicting the metabolism and metabolic interactions of drugs and chemicals which are likely to occur following their exposure in man and compare these with results in vivo.
Programme: FP4-BIOMED 2
Record Number: 32506
Last updated on: 2000-09-21
ID: BMH4960310
Start date: 1996-05-01, End date: 1999-04-30
To search systematically for morphogenic genes (gene disruption by transposon insertion, differential mRNA display) To analyse the early events in morphogenesis involved in the regulation of the cell cycle and the transcription regulation To analyse the late events, e.g. th...
Programme: FP4-BIOMED 2
Record Number: 31886
Last updated on: 1997-07-29
We have developed a very sensitive microassay, which allows to accurately measure low amounts of steroids in small tissue samples. It is based on the extraction of steroids from tissue, their separation by gas chromatography (GC) and their identification by mass spectrometry (...
Programme: FP4-BIOMED 2
Record Number: 27109
Last updated on: 2003-01-17
ID: BMH4972359
Start date: 1997-12-01, End date: 2000-11-30
To study the mechanisms by which neurosteroids increase the expression of specific myelin proteins. To test the beneficial effects of neurosteroids in transgenic animal models for hereditary peripheral neuropathies. To determine whether neurosteroids promote myelination in the...
Programme: FP4-BIOMED 2
Record Number: 38960
Last updated on: 2001-12-07
ID: BMH4972093
Start date: 1997-07-01, End date: 2000-09-30
Cellular and sub-cellular localization of GABAB receptor subtype(s) in the cortex, thalamus and spinal cord. Physiological function(s) of GABAB receptor subtype(s) investigated by biochemical, ion imaging, and in vitro and in vivo electrophysiological techniques in the cortex,...
Programme: FP4-BIOMED 2
Record Number: 37586
Last updated on: 2002-04-22
ID: BMH4961081
Start date: 1996-07-01, End date: 2000-12-31
(1) Technology-related: Finding, designing and synthesis of a sensitive and PNA:NAspecific dye; fixation of PNA on useful solid supports; specific hybridisation of DNA with solid support-bound PNA; detection of PNA:NA hybrids by specific dye interaction; development of bread b...
Programme: FP4-BIOMED 2
Record Number: 32487
Last updated on: 2001-12-07
ID: BMH4982239
Start date: 1998-10-01, End date: 2001-02-28
The major objective of this proposal i8 to develop strategies to design a vaccine against the hepatitis C virus (HCV) through the analysis of the HCV specific immune response. In addition, the involvement of members of the combined group in vaccine development means that the...
Programme: FP4-BIOMED 2
Record Number: 45577
Last updated on: 1999-02-16
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List retrieved on: 2018-04-24
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